This study uncovers a #lncRNA-derived #microprotein, TPM3P9, that drives #ClearCellRenalCellCarcinoma by binding RBM4 to alter #TCF7L2 splicing and activate NF-κB signaling, highlighting TPM3P9 as a therapeutic target in renal cancer. #medsky

#STTT: doi.org/10.1038/s413...

Researchers discover new #microprotein that controls #metabolic #health in #mouse #fatcells

Salk researchers found a microprotein, once thought genetic junk, is crucial for mitochondrial health. It could lead to new treatments for obesity and aging scitechupdates.com/r...

In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component The dark proteome includes a rapidly expanding catalog of microproteins with unknown functions that have been historically ignored in genome annotations. Here, we exploit an in vivo single-cell CRISPR...

There is a new must-read paper for the weekend. 👀

Looking for the next future vision of #microprotein research? Check out this from @fabiolavaldiviaf.bsky.social @sendoellab.bsky.social.

Really, what can't microproteins do?

#RNAsky
#genomics
#bioinformatics
🧬 💻

www.biorxiv.org/content/10.1...

Excited to share our lab’s latest preprint: In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component.

Check out how we systematically explore #microprotein functions and how they expand the cellular proteome!

So happy with how #KSMicroproteins25 came together and just hearing all the wonderful responses from attendees! Honestly it was best meeting I've ever attended (yes I'm biased but regardless!). Our #microprotein community is so special and it keeps me going even amidst all the ongoing chaos.

Comprehensive discovery and functional characterization of the noncanonical proteome - Cell Research Cell Research - Comprehensive discovery and functional characterization of the noncanonical proteome

Sometimes the #microprotein field needs to police itself.

I rarely see the point in sharing disapproval for published papers. Let bygones be bygones, I suppose.

Several days ago, however, a new paper came out. My assessment is that it is bogus.

#genomics
🧬 💻

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www.nature.com/articles/s41...

Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...

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it's a Merry #Microprotein Christmas! We're uncovering more new uncharacterized MPs in our models to study.

Folks often ask where they are in cells, and the answer is that they're as diverse as the larger proteins we're all familiar with. Any guesses where some of our new friends are localized?🔬

with Dörte's paper soon out in a journal (but not too late to read on bioRxiv, PM me for revised version www.biorxiv.org/content/10.1...),
it is time for a new #microprotein preprint 👇

Please RT: Calling all #microprotein enthusiasts! Dive into cross-kingdom communication with our postdoc fellowship @umeauniversity mentored by @microProteins & @CavaLab_MIMS. Apply now:  CROSS-COMM #Postdoc #Research project #10: shorturl.at/clxXZ