Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.

#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc

🤔 Personalize #immunosuppression, ie #tacrolimus, in kidney txp patients?

@drpriyajohn discusses the tacrolimus C/D ratio & potential shift in transplant care

Infographic by @krithicism

https://ow.ly/rMPG50XhaUy

https://ow.ly/5PiE50XhaUs

THE JULY ISSUE IS ONLINE!!

How can we find a balance between Tacrolimus, BK virus and HLA?

Check it out here: shorturl.at/VwJnS

#july #issue #balance #tacrolimus #HLA #BKvirus @esottransplant.bsky.social

TAC Beats MMF for Relapse-Free Survival in Pediatric Nephrotic Syndrome | Docwire News Tacrolimus significantly extended relapse-free survival for children with frequently relapsing or steroid-dependent nephrotic syndrome compared with mycophenolate mofetil.

Tacrolimus significantly extended relapse-free survival for children with nephrotic syndrome. #nephsky #nephrology #nephroticsyndrome #pediatrics #tacrolimus #mycophenolatemofetil www.docwirenews.com/post/tac-bea...

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#Saçtapullanma #Saçtakabuklanma #psoriazis #Etkilitedavi #seboreikdermatit #saçlosyonu #tacrolimus #salisilikasit #clobetasol #kişiyeözel #majistral #uygareczanesi
www.instagram.com/reel/DH8_YN0...

Early Determination of #Tacrolimus Concentration-dose Ratio Identifies Risk of #AllograftLoss in Kidney #Transplantation

#VisualAbstract by @nephroseeker.medsky.social

www.kireports.org/ar...

Word of the week: #Tacrolimus

Learn more about commonly prescribed drugs here: www.kidney.org.uk/commonly-pre...

Cooling therapy and tacrolimus induced tremors » Norman ... Researchers discover using icepacks on the arms and hands...

fixel.ufhealth.org/2023/02/08/cooling-thera...

#Tacrolimus #Tremor #TacrolimusTremor

🧵(5/5)

So, been reading anything interesting lately? #drugfacts #atopicdermatitis #tacrolimus #letstrythis www.instagram.com/p/B7oo967ipp5/