PROTACs improve selectivity for targeted proteins
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#PROTAC #ProteinSelectivity #TargetedDegradation #DrugDesign #ChemicalBiology

Multi-specific antiviral PROTAC modality
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#PROTAC #Antiviral #TargetedDegradation #DrugDiscovery #ChemicalBiology

PROTAC degraders recruiting MDM2
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#PROTAC #MDM2 #E3Ligase #TargetedDegradation #DrugDesign

Computational strategies accelerating PROTAC discovery—driving next-generation targeted therapeutics
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#PROTAC #DrugDiscovery #ComputationalChemistry #TargetedDegradation

SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...

Selinexor is an allosteric degrader. It stabilizes XPO1/CRM1 to expose a cryptic ASB8 E3 ligase site, triggering ubiquitination. Led by Casey Wing, Joyce Fung & Bert Kwanten. #TargetedDegradation #Allostery

Some of our recent work on models to design molecular glues, PROTACs (and really anything that forms a protein-protein complex) -- presented by Aram Davtyan at Keystone on Proximity-based Therapeutics this week!

#targetedDegradation #PROTAC #molecularGlue #drugDev #drugDesign #biotech #bioSky