Day 7: Resistance to #teicoplanin is rarer than for vancomycin but growing concern in UK re acquired resistance eg MRSA, E.faecium, S haemolyticus & coagulase neg staphylococci. Multiple mechanisms include increased cell wall thickness & changed cell wall structure reducing drug affinity
Day 6: There are no specified drug-drug interactions for #teicoplanin in the BNF. Caution for all drugs which can cause nephrotoxicity e.g ciclosporin, furosemide (NOT exhaustive)
Day 5: #teicoplanin ADEs: Common include: fever, pain, rash. Uncommon include:hypersensitivity, ototoxicity, diarrhoea, N&V. Frequency not known include:nephrotoxicity, SCARs, seizure. Prolonged use can cause superinfection. (NOT exhaustive)
Day 4: #teicoplanin is 1 of 2 ‘glycopeptide’ antibiotics; other is vancomycin. The mechanism of action is inhibition of bacterial cell wall synthesis by binding to peptidoglycan (PG) precursors. This is distinct from penicillins; these target the enzymes which cross link PG chains in cell wall
Day 3(cont) #teicoplanin has a relatively narrow therapeutic index. Therapeutic drug monitoring of trough concentrations required. Renal impairment warrants dose/interval adjustment
Day 3: Parenteral delivery of #teicoplanin yields high bioavailability. High protein binding & good Vd. Penetration to bone/synovium, soft tissues, lungs, heart, kidney. Poor reach to CNS. Minimal metabolism, renal excretion as unchanged drug. Long t½ up to 100hrs @steady state >needs loading dose
Day 2 (cont) #teicoplanin taken by mouth only for C.difficile 100-200mg twice daily for 7-14 days;#teicoplanin is not absorbed from gut, so high concentration in gut to manage C.difficile
Day 2: #teicoplanin is used i.m/i.v for serious gram-positive infections: complicated soft tissue /urinary tract/lung infections, diabetic foot infections, bone & joint infections. Unlicensed use surgical prophylaxis. Dosing regimens by weight & varied re infection/site
Day 1: Isolated in 1970s from an Indian soil sample #teicoplanin is derived from the bacterium Actinoplanes teichomyceticus. The structure was revealed in 1980s & the drug licensed in Europe 1988. Remains unlicensed by FDA
New series '7 days of #teicoplanin' starting today
#Medsky🧪 #IDsky #pedsky #oncosky #pharmasky
#Teicoplanin is commonly used in children to treat gram-positive infections & is sometimes used off-label prophylactically in surgical or pediatric oncology settings. The pharmacokinetics (PK) of teicoplanin in children exhibit considerable variability,
Parenteral Antibiotics & Respiratory Meds: Brands & Dosages
#Montika #Salmeterol #Seretide #Fluticasone #Salmicort #Beclomethasone #Bekson #Ventide #Piperacillin #Tazobactam #Tanzo #Tazocin #Teicoplanin #Targocid #Imipenem #Cilastatin #Tienam #Meropenem
