Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social

#HistoryOfMedicine #EBM #EBHC #RCT

#TrialsTuesday #6
Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation by comparing it to “sham surgery” 1/8

Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social

#HistoryOfMedicine #EBM #EBHC #RCT

#TrialsTuesday #5
Gold featured as an ineffective treatment for tuberculosis in last week's Trials Tuesday. This week, I feature a person who shares the name of the element - Harry Gold – to illustrate the history of the "double blind" trial. 1/8 #DoubleBlind #HistoryofMedicine

Learn about fair tests of treatment through history, in the #TrialsTuesday series from @jameslindlibrary.bsky.social

#HistoryOfMedicine #EBM #EBHC #RCT

#TrialsTuesday #4 The last TrialsTuesday was the MRC trial of streptomycin for TB that used random numbers to fill envelopes which, when opened, revealed a patient’s assigned treatment. But, what about using a more familiar method for using chance to choose between options: flipping a coin? 1/8

Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT

TrialsTuesday #3
Last #TrialsTuesday, I featured the #MRC 1944 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948. 1/8 @bmj.com

Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social

#HistoryOfMedicine #EBM #EBHC #RCT

#TrialsTuesday #2 Last week, I reminded you of my trial of oranges and lemons for scurvy. This week, it’s something from a mould that grows on apples, which was tested as a treatment for the common cold nearly 200 years later in the UK Medical Research Council (MRC) 1944 trial of patulin. 1/8

Learn about fair tests of treatment through history, in the #TrialsTuesday series from @jameslindlibrary.bsky.social
#HistoryOfMedicine #EBM #EBHC #RCT

#TrialsTuesday #1 On this first Tuesday of 2026, I’m relaunching Trials Tuesday to illustrate the development of fair tests of treatment through history, featuring important clinical trials. I begin with my study of scurvy on board the Salisbury. 1/8 www.jameslindlibrary.org/articles/who...

5/8 They were randomised to aspirin, streptokinase, both or neither in what’s called a factorial trial, which will feature more in a future #TrialsTuesday. This meant that half the patients got aspirin and half did not.

#TrialsTuesday #9 In recent weeks, Trials Tuesday has highlighted some small, practice changing trials. In contrast, today’s trial is one that was described as “massive” by Keith Veronese in Making Medicine. It was called ISIS-2. 1/8

Here's a great example of how Trials Change Lives #ProstateCancer. It's #InternationalClinicalTrialsDay and you can watch for weekly #TrialsTuesday posts by following ‬
‪@jameslindlibrary.bsky.social‬

Docetaxel and/or zoledronic acid for hormone-naïve prostate cancer: First overall survival results from STAMPEDE (NCT00268476). 5001 Background: STAMPEDE is a randomised controlled trial using a novel multi-arm multi-stage design. It recruits men (pts) with high-risk locally advanced or metastatic prostate cancer (PCa) start...

#TrialsTuesday #8 1/8 On #InternationalClinicalTrialsDay 2025, we feature STAMPEDE, a trial that started in 2005 and announced its first practice changing results 10 years ago today, to the American Society of Oncology ascopubs.org/doi/10.1200/... @ascocancer.bsky.social‬ @mrcctu.bsky.social‬

#TrialsTuesday #7. Today, I’ll take you more than 100 years further back in time than my trial of scurvy. I’ll share with you a proposal for a study that highlighted the need for fair tests when a common treatment might do more harm than good #FairTest #TestingTreatments 1/8

#TrialsTuesday #6 Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation, by comparing it to “sham surgery” 1/8

#TrialsTuesday #5. Gold featured as an ineffective treatment for tuberculosis in the last TrialsTuesday. This week, I feature a person who shares the name of the element - Harry Gold – and the history of the "double blind" trial 1/8 #DoubleBlind

#TrialsTuesday #4 Last week’s TrialsTuesday was the MRC trial of streptomycin for TB which used random numbers to fill envelopes that, when opened, revealed a patient’s assigned treatment. But, what about using a more familiar method for using chance to choose between options: flipping a coin? 1/8

TrialsTuesday #3 Last #TrialsTuesday, I featured the #MRC 1994 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948 1/8 @bmj.com

#TrialsTuesday #2 Last week, I reminded you of my trial of oranges and lemons for scurvy. This week it’s apples, or more precisely a substance from a mould that grows on apples, and testing it as a treatment for the common cold. It’s the Medical Research Council’s 1944 trial of patulin 1/8

#TrialsTuesday #1 Starting today, every Tuesday here in Bluesky, I’ll tell you about an important clinical trial. Where better to begin than with my own study of treatments for scurvy on board the gun ship, Salisbury 1/8