Muscle-Mural Lineage fates of embryonic TNAP+ progenitor (e11.5)

Skeletal myocyte
#MuscleStemCell 4%
#SmoothMuscleCell 7%
#Pericyte 20%

Fate window closed by e14.5

TNAP-CreERT2::nLacZ or Confetti🐭

Giulio Cossu lab #VasPharma 2025
www.sciencedirect.com/science/arti...

Cdc42 coordinates PDGFRb+ Mural Cell migration proliferation morphogenesis (wrapping filopodia) during postanatal retinal #Angiogenesis👁️

PDGFRb+ mural cell Cdc42 KO🐭➡️
⏫Angiogenic front leakage
⏬Tip cell filopodia
Perturbed arterial patterning

#VasPharma 2025
www.sciencedirect.com/science/arti...