🚀From Bench to Paper | 🌟Great to see this work in Nature #Metabolism, uncovering the stem cell-fate regulatory roles of #CMA. #QX77 was used to rescue defective #muscle #regeneration in old mice. ✨We provide QX77 for research use only: www.medchemexpress.com/QX77.html
#MuscleStemCell #AgingResearch

Muscle-Mural Lineage fates of embryonic TNAP+ progenitor (e11.5)

Skeletal myocyte
#MuscleStemCell 4%
#SmoothMuscleCell 7%
#Pericyte 20%

Fate window closed by e14.5

TNAP-CreERT2::nLacZ or Confetti🐭

Giulio Cossu lab #VasPharma 2025
www.sciencedirect.com/science/arti...

#MuscleStemCell #SatelliteCell express low-level but Functional FLT1, NRP1, NRP2 proteins

VEGFA-Flt1 cascade protect MuSC from Apoptosis in cluture & ⏫#SkeletalMuscle regeneration (BaCl2, Cardiotoxin) & ameliorate muscle injury in Mdx mice

#eLife 2024
elifesciences.org/articles/73592

#Ferroptosis of #MuscleStemCell in Myopathy #PeripheralArteryDisease

scRNAseq CD56+ MuSC
4 perfused/thigh vs 4 ischemic/calf muscle👤

Interesting Lipofuscin stain pattern
Ferroptosis also in non-satellite cells?🤔

Ulka Sachdev lab #ATVB 2023
www.ahajournals.org/doi/abs/10.1...