Synapse: Your Connection to our MSK Authors
Meet: Kevin Chen
Research Focus: Research Facilities; Research Assistant
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
synapse.mskcc.org/synapse/work...
#VEXAS #AutoinflammatoryDisease #MyeloidDisorders
#MedCase - Learn about the neurological symptoms of #VEXAS syndrome in this 58-year-old patient with a biopsy supporting central demyelination.
👉 buff.ly/jlA8VnE
#RheumSky
Excited to see our review on #VEXAS now out in @thelancet.com A collaborative effort from our amazing NIAMS and NHLBI VEXAS team Bhavisha Patel, Peter Grayson, Alice Fike, Kaitlin Quinn, Ben Turturice www.sciencedirect.com/science/arti...
A team at MSK is shedding new light on #VEXAS syndrome, a severe autoinflammatory condition arising from a mutation in the UBA1 gene.
“We are hopeful that the therapeutic targets identified by our research can pave the way for new approaches.” says @gitlinlabmsk.bsky.social.
bit.ly/4oRQ5LF
#VEXAS Syndrome new paper alert!!
New article to read! Characterizing VEXAS syndrome in women.
➡️ An autoinflammatory disease
➡️ Caused by somatic UBA1 mutations on the X chromosome
➡️ Findings from an international multicenter study
🔗 doi.org/10.1111/joim.70023
#VEXAS #autoinflammatory
Our October issue is live!
Including research on #vaccination in #rheumatoidarthritis and
#hydroxychloroquine during #pregnancy, two Reviews on #VEXAS, plus much more! thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky
#MedCase - Explore 2 cases highlighting the diagnostic and therapeutic complexities of #VEXAS syndrome, a recently identified autoinflammatory disorder caused by somatic UBA1 mutations.
👉https://buff.ly/vRN9FIm
#RheumSky #MedSky
FAI²R a lu pour vous : ⤵️
📚 Syndrome VEXAS : résultats d'une cohorte britannique sur l’efficacité des traitements ciblés.
💬 Résumé par la Professeure Sophie Georgin-Lavialle
🔗Lire le résumé : drive.google.com/file/d/1f2Am...
#FAI2R
#FSMR
#Vexas
Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...
NEW podcast episode🎧
Deputy Editor, Sophie Woolven, talks to Siniša Savić about treatment outcomes in #VEXAS syndrome
👉Apple: bit.ly/3THLJJq
👉Spotify: bit.ly/4naUdX7
Full Article: www.thelancet.com/journals/lan...
🚨 SAVE THE DATE 🚨
🧬 2nd International VEXAS Workshop – 2025
📅 25 & 26 septembre 2025
📍 NYU Grossman School of Medicine – New York
📘 Programme complet : www.highmarksce.com/nyumc/index....
🖊️ Les inscriptions ouvriront très bientôt.
👉 Restez connectés pour ne rien manquer !
#VEXAS #Workshop
FAI²R a lu pour vous : ⤵️
📚 Efficacité et tolérance de l’azacitidine dans le syndrome VEXAS : données rétrospectives de la cohorte française FRENVEX.
💬 Résumé par le Docteur Philippe Mertz
🔗Lire le résumé : drive.google.com/file/d/1MYgO...
#FAI2R
#FSMR
#Vexas
Our July issue is live!
Including research on patient-reported outcomes in #SLE, #SystemicSclerosis associated #ILD, autoimmune diseases during #pregnancy, and treatment outcomes in #VEXAS syndrome, plus much more! www.thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky
NEW RESEARCH—A retrospective cohort study from the UK reports treatment outcomes of targeted therapies in patients with #VEXAS syndrome thelancet.com/journals/lan...
Plus linked Comment www.thelancet.com/journals/lan...
#Medsky #Rheumsky
Sobi's Upcoming Presentation of Clinical Data at EULAR 2025 Conference #Sweden #Stockholm #Sobi #Gamifant #VEXAS
Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young
Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...
FAI²R a lu pour vous : ⤵️
📚 Le syndrome VEXAS à travers le regard d’un rhumatologue : enseignements tirés d’une cohorte nationale espagnole.
💬 Résumé par la Professeure Sophie Georgin-Lavialle
🔗Lire le résumé : lnkd.in/eXpwPKvw
#Vexas
Key points from #ISSAID2025
This #autoinflammatory disease congress wouldn't have been complete without some updates on #VEXAS syndrome:
- new "VEXAS man" schema, with updated manifestations
- better defined risk factors for a worse prognosis
- VEXAS-like syndromes DO exist!!
#rheumsky #medsky
Very nice paper published in @natmedicine.bsky.social from the 🇮🇹 San Raffaele group showing upregulation of inflammatory and senescence markers in #VEXAS HSPCs with exhaustion of surrounding wild type cells. www.nature.com/articles/s41...
Unfortunately was not able to travel to EBMT but our poster can still be viewed virtually! We report on the first 7 #VEXAS patients who underwent allo-HCT on our prospective phase II trial. High rates of #GVHD and other inflammatory complications noted. @ Bhavisha Patel
Congratulations to Chloe Grolleau, @sophiegeorgin.bsky.social, @terrierben.bsky.social and the entire team behind this beautiful work analysing the inflammatory signatures seen in #VEXAS, MDS-cutis and refractory Sweet syndrome lesions.
#medsky #rheumsky #dermsky
jamanetwork.com/journals/jam...
Improving Outcomes in VEXAS Syndrome: The Need for Prospective Data
#VEXAS #Rheumatology
academic.oup.com/rheumatology...
Syndrome VEXAS - Par Paul Breillat (interne en Médecine Interne, Paris, France) #VEXAS #InternistAcademy 2024
VEXAS syndrome - By Paul Breillat (fellow in Internal Medicine Paris, France) #VEXAS #InternistAcademy 2024
Check out my NHLBI colleague Bhavisha Patel‘s poster reporting our work in patient reported outcomes in #VEXAS. Patients reported high symptom burden. #ASH24 @ash-hematology.bsky.social
Interesting talk from Olivier Hermine from Necker, Paris looking at the mechanisms underlying erythroblastopenia in #VEXAS - possible role of defects in ubiquitination and ribosomes. #ASH24 @ash-hematology.bsky.social
Excellent update on #VEXAS by my colleague Bhavisha Patel from NHLBI highlighting ongoing therapeutic approaches and challenges. #ESHBMFS2024
![Portal venous phasic abdominal and pelvic computer tomography and intravenous pyelography without dual-energy technique demonstrated right ureteric wall thickening, uretopelvicaliectasis secondary to long segment, circumferential thickening of the proximal third of the right ureter with periureteric fat stranding, normal cortical thickness, and delayed nephrogram without ureterolithiasis (coronal image in A; axial in B). [complete case in article]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:g5fr5vggcyl7dq3ub7zmdwrz/bafkreigvt6xuyrv7i6eqvgdudg27o7yhw7w747etuyn4nrvg3pllqzszye)
Portal venous phasic abdominal and pelvic computer tomography and intravenous pyelography without dual-energy technique demonstrated right ureteric wall thickening, uretopelvicaliectasis secondary to long segment, circumferential thickening of the proximal third of the right ureter with periureteric fat stranding, normal cortical thickness, and delayed nephrogram without ureterolithiasis (coronal image in A; axial in B). [complete case in article]
Clinical Images: Ureteritis in #VEXAS syndrome
In ACR Open Rheumatology
loom.ly/BSA-M5E
A 75-year-old man with VEXAS syndrome treated with glucocorticoids, methotrexate, and tocilizumab, presented with severe, acute right flank pain
🩺 RheumSky
