☕The authors show that increased #Xist RNA levels can induce de novo silencing of genes that normally escape #Xinactivation. SPEN depletion prevents the silencing of escape genes upon Xist RNA overexpression in neural progenitors. @agneseloda.bsky.social @heardlab.bsky.social
bit.ly/3YUnzhw
Epigenetics Update - Escape from X inactivation is directly modulated by Xist noncoding RNA go.nature.com/49jeLH5
Edith Heard and Agnese Loda (EMBL) reporting in Nat Cell Biol
#Epigenetics #Xist #XInactivation #Chromatin
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Perfect for cancer, immunology, and aging research; epigenometech.com
Runumi, from our lab, had a fantastic week at the @embo.org Epitranscriptome workshop at EMBL Heidelberg! She presented her work on the role of m6A RNA modification in #embryogenesis #stemcell specification and #Xinactivation. #EMBOEpitrans
Thanks to IISc, ANRF-India, DBT-India, @insdb.bsky.social
#quotes #books #booksky #excerpts #citations #evolutioninfourdimensions #evolution #inheritance #jablonka #lamb #zeligowski #xchromosome #sex #chromosome #female #women #inactivation #epigenetic #xinactivation
We solved a puzzling case of Incontinentia Pigmenti by phasing a pathogenic variant in IKBKG to the preferentially inactivated X chromosome and at the same time discriminating gene from pseudogene using #Nanopore long reads.
#HumanGenetics #IncontinentiaPigmenti #XInactivation #LongReads
Longhaired calico cat beginning to roll upside down on a cardboard scratch pad.
Now that I have some followers it's time to show off my rescue cat, Fluffernutter Purrington. Still kind of feral but loves having her belly rubbed. #cat #caturday #Xinactivation
