This review highlights #disulfidptosis as an emerging regulated cell death pathway in #cancer, linked to #CystineMetabolism and #ActinRemodeling, summarizing mechanisms, bioinformatics-based #biomarkers, therapeutic potential, and challenges.

#OpenAccess: doi.org/10.1016/j.ge...

Researchers identify #CDC6 as a key regulator of #paclitaxel resistance, showing that its interaction with Tmod3 stabilizes CDC6 to drive #actinremodeling, while CDC6 depletion or actin-targeted combination therapy resensitizes tumors.

#OpenAccess in #STTT: doi.org/10.1038/s413...