Moracin M derivative targeting PDE4 for the treatment of psoriasis LW, a Moracin M derivative, inhibits Phosphodiesterase-4 (PDE4), reduces inflammation, and improves psoriasis symptoms, showing strong therapeutic potential with fewer side effects.

LW, a #MoracinM derivative, inhibits #PDE4, reduces inflammation, and improves psoriasis symptoms, showing strong therapeutic potential with fewer side effects.

Read More: tinyurl.com/3pvwextj

#PDE4inhibitor #psoriasis #inflammatoryfactor #AMMJournal @scienceopen.bsky.social

Berberine inhibits phagocytosis through the TLR4-PI3K-CDC42 pathway Berberine inhibits phagocytosis and inflammation via the TLR4-PI3K-CDC42 pathway, suppressing NF-κB signaling and key inflammatory markers in macrophages.

Berberine (BBR) inhibits phagocytosis and inflammation via the TLR4-PI3K-CDC42 pathway, suppressing NF-κB signaling and key inflammatory markers in #macrophages.

Read More: tinyurl.com/4ktmt2pd

#Berberine #Phagocytosis #TLR4-PI3K-CDC42 #AMMJournal @scienceopen.bsky.social

Antineoplastic effects of icaritin: molecular mechanisms and applications Antineoplastic effects of Icaritin acting through various molecular mechanisms. Its potential applications in cancer therapy continue to expand.

Antineoplastic effects of #Icaritin acting through various molecular mechanisms. Its potential applications in #cancertherapy continue to expand.

Read More: tinyurl.com/2e67ex3e

#traditionalChinesemedicine #hepatocellularcarcinoma #molecularmechanism #ammjournal @scienceopen.bsky.social

Progress in the structural modification and pharmacological activity of isosteviol Isosteviol and its derivatives, diterpene compounds with a wide range of biological activities, play important antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyret...

Exploring the #pharmacologicalactivity of #isosteviol! From antiviral to anti-inflammatory benefits, its potential in drug discovery is immense. Stay tuned for breakthroughs in medicinal chemistry.

Read More: tinyurl.com/5bzv345u

#Isosteviol #Diterpene #ammjournal @scienceopen.bsky.social

Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis Single-cell RNA-seq reveals RNA binding proteins dysregulation in RA vs OA, altering splicing & signaling; new therapeutic targets emerge! right now!!

#SinglecellRNA-seq reveals #RNA binding proteins dysregulation in RA vs OA, altering splicing & signaling; new therapeutic targets emerge! right now!!

Read More: tinyurl.com/ycj5b6m9

#scRNAseq #rheumatoidarthritis #celltocellcommunication #fibroblasts #ammjournal @scienceopen.bsky.social

MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 miR-128-3p promotes MRP2 internalization by inhibiting PDZK1, contributing to estrogen-induced cholestasis. Restoring PDZK1 may offer therapeutic potential.

#miR1283p promotes #MRP2 internalization by inhibiting #PDZK1, contributing to #estrogeninducedcholestasis. Restoring PDZK1 may offer therapeutic potential.

Read More: tinyurl.com/yc6wf3kd

#localization #ammjournal @scienceopen.bsky.social