However, new research shows the picture is more nuanced than we thought. Not everyone with two copies develops disease, and we've discovered a protective modifier variant called M1 that can lower risk when it's inherited with the G2 variant. #apol1 #renal

When can we expect #APOL1 channel inhibitors get @fda.gov approval? @asnkidney.bsky.social @vertexpharm.bsky.social #amkd @kidneyfund.bsky.social

Bar graph titled "Frequency of the M1 variant in individuals with APOL1-HR high-risk genotypes". X axis: Clinical diagnosis (FSGS/SRNS, Non-FSGS CKD, Controls). Y axis: Proportion with M1 (p.N264K). P=text@1, P=text@2, and P=text@3.

Among patients with high-risk #APOL1 genotypes, presence of the M1 (p.N264K) variant was associated with improved diagnostic precision for #KidneyDisease, but no protection in low-risk genotypes.

ja.ma/4lme1pY

Precision Diagnosis in APOL1 Kidney Disease With p.N264K M1 Protective Variant This case-control study evaluates whether, in patients with APOL1 high-risk genotype kidney disease with at least 1 G2 allele, M1 can distinguish APOL1 chronic kidney disease from non-APOL1 chronic ki...

Online today on @jamanetworkopen.com our new paper on the role of #APOL1 M1 in increasing precision diagnosis for CKD in individuals from African ancestry.
Collaboration with
@kidneyomicsamps.bsky.social @gbadegesinlab.bsky.social @kirylukk.bsky.social et al

jamanetwork.com/journals/jam...

Kidney Commute NKF Mega Menu

How do genetics and environment intersect in kidney disease? Hear clinician and patient perspectives on APOL1 mediated kidney disease in our latest episode.

Supported by Vertex Pharmaceuticals.

🎧 bit.ly/3DamjQ9

#Nephrology #KidneyDisease #APOL1 #KidneyHealth

Great paper !!!
#APOL1 #FSGS

New in JASN: CARE shows a hybrid path to equitable APOL1-kidney disease (AMKD) screening + trial pipelines—community partnerships = reach, EHR/MD referrals = yield.
journals.lww.com/jasn/pages/a...
#Nephrology #KidneyDisease #APOL1 #AMKD #HealthEquity #ClinicalTrials #PrecisionMedicine #JASN

Editorial: Special Report
ICD-10 codes for APOL1-mediated kidney disease

doi.org/10.1016/j.kint.2025.09.025

#NephSky #MedSky #chronickidneydisease #FSGS #APOL1 @wakeforestmed.bsky.social

Your kidneys may feel fine — but “normal” numbers can mislead, especially if you’re Black or of African ancestry. The KDIGO Heat Map shows your real risk using eGFR + uACR. Ask your doctor for your numbers. Knowledge = power. 🩺

#KidneyHealth #AMKD #APOL1 #HealthEquity

Check out the December issue of KDIGO Direct: kdigo.co/KDIGO-Direct...

In this issue:
- Controversies Conference on Tech in Guideline-Informed Care
- KDIGO convenes Executive Committee
- KDIGO at ASN #KidneyWk
- New KDIGO #APOL1 and #IgAN podcast episodes!
- Upcoming activities & new resources

Inflammation-linked apolipoprotein-L activities: immunity control, mitochondrial repair, pathogen resistance, and disease induction
#OpenAccess in #RegenerativeMedicineReports: doi.org/10.4103/REGE...
#APOL1 #KidneyDisease #Inflammation #Mitochondria #RegenerativeMedicine #Immunology #CellBiology

Silent kidney damage is real. For people of African ancestry at risk for AMKD, the KDIGO Heat Map turns confusion into control. Two tests—eGFR + uACR—show your risk in color-coded zones 🟢🟡🟠🔴. Ask for both tests. Know your zone. Protect your future.

#AMKD #APOL1 #KidneyHealth

Interesting read on the protective p.N264k (M1) #APOL1 variant and #kidneydisease and #FSGS.
More to come soon on M1…. Stay tuned :)

@bhallaresearch.bsky.social
@gbadegesinlab.bsky.social @kidneyomicsamps.bsky.social

#Dengue Infection as a Trigger for #Collapsing #Glomerulopathy in Patients With #APOL1 High-Risk Genotype

https://doi.org/10.1016/j.ekir.2025.08.005

#KIRNephrologyRounds

“Your kidney numbers look fine.” Sounds safe — but for many with APOL1 risk, it’s dangerously misleading. The KDIGO Heat Map pairs eGFR + uACR to reveal your real risk. Ask for both tests, know your zone, protect your kidneys.

#AMKD #APOL1 #KidneyHealth

Thank you @asnpublications.bsky.social !!!
This is a true honor, and a sprinkle of good luck!

#FSGS #rFSGS #raredisease #APOL1 #CAKUT #NephSky #SkyNeph
@asnkidney.bsky.social
@isgd.bsky.social

Your kidneys might be at risk — even if your doctor says you're “fine.” 🧡 The KDIGO Heat Map combines eGFR + uACR to reveal your true risk. Ask for both tests, find your zone, and take control of your kidney health. Knowledge = power. 🗺️✨

#KidneyHealth #AMKD #APOL1

New KDIGO #APOL1 podcast series! Listen now: kdigo.co/Conversations-in-Nephrology-Podcast

Hosted by Kirk Campbell, with:
#26: Bessie Young on burden & biology
#27: Barry Freedman on management & emerging therapies
#28: Titilayo Ilori & patient advocate Joshua Albright on screening & early detection

🔒 Most people at high risk for APOL1-mediated kidney disease don’t know it.
A simple test can reveal your risk & help protect your kidneys.
Don’t wait for symptoms — know your status, act early, protect your future.

#APOL1 #KidneyHealth #BlackHealth

Highly recommended contribution from Detlef Bockenhauer et al: a modern view of the genetic landscape of kidney diseases!
#genetics #CAKUT #FSGS #APOL1 #NephSky #SkyNeph #Medsky #raredisease #RKD
@melaniechan.bsky.social @oalavijeh.bsky.social @horiastanescu.bsky.social @dannygale.bsky.social

I thought my kidney issues were stress—fatigue, swelling, “normal” labs. Then I learned about APOL1, a gene common in people of African ancestry. Two variants = higher kidney disease risk. Get tested. Know your risk. Protect your kidneys. 🧬💜 #APOL1 #KidneyHealth

Exciting expansion!!
#FSGS #APOL1

🧬 Your Genes, Your Kidneys 🧬
More than 4M African Americans may carry high-risk APOL1 gene variants—most don’t know it.
Silent damage. Delayed diagnosis.
Knowledge = Power. 💡

Ask for APOL1 testing + eGFR + uACR.
Early action saves kidneys. 🫶

#KidneyHealth #APOL1 #GeneticTesting #HealthEquity

Your kidneys may “look fine” — but if you’re of African ancestry, a hidden genetic risk could change everything. APOL1 variants silently increase the risk of kidney disease for millions. Ask. Get tested. Protect your future.
#APOL1 #KidneyHealth #BlackHealth

🧬 About 13% of African Americans carry APOL1 gene variants (G1 & G2) that raise the risk of AMKD, a silent kidney disease that can go unnoticed until it’s advanced.

💡 Ask your doctor about APOL1 testing + eGFR & uACR tests.
Knowledge = Power. 🖤

#APOL1 #KidneyHealth

APOL1 Nephropathy | Understanding Genetic Risk in Kidney Disease 🩺
#APOL1 #Nephropathy #KidneyHealth #MedicalAwareness #VikaasShandily

The Two Levels of Podocyte Dysfunctions Induced by Apolipoprotein L1 Risk Variants
#OpenAccess
Full text 👉 buff.ly/eNYwDuQ

#APOL1
#nephropathy
#podocyte
#dysfunction
#apoptosis
#Nephrology
#KidneyCare
#nephsky
#medsky
#RenalPath

Working from home with these two cuties can be soothing and boost productivity ❤️
#NephSky #raredisease #APOL1 #FSGS #CAKUT

Mutations driving evolution are informed by the genome, not random, study suggests A study published in the Proceedings of the National Academy of Sciences by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not randomly but more frequently where it is needed to prevent disease, fundamentally challenging the notion that evolution is driven by random mutations and tying the results to a new theory that, for the first time, offers a new concept for how mutations arise.

🤯 Evolution isn't *just* random! New research reveals mutations can arise where *needed* to fight disease! ✨ A groundbreaking theory emerges! 🧬 #APOL1

Source: phys.org/news/2025-09-mutations-e...

Thank you @opeyemiolabisi.bsky.social and the whole @dukekidney.bsky.social , @gbadegesinlab.bsky.social , Laura Barisoni et al!
It was a great couple of days of scientific excellence mixed with pleasant company and nice weather.
#APOL1 #FSGS #rFSGS #genetics #pediatrics #NephSky #SkyNeph #Medsky