The ALBICS-AKI trial was published recently in JAMA Surgery
during #CCR25
The recording of the presentation is available from CCR Down Under
criticalcarereviews.com/meetings/ccr...
Paper -> jamanetwork.com/journals/jam...
Episode 67! A simple one this time. Just a 50,000 ft overview of the presentations from the #CCR25 conference!
🎧https://pod.link/1667336877
@criticalcarereviews.com
An image of a simulated Kaplan-Meier curve
A few people asked me for this clinical trial simulator after #CCR25 so here it is for anyone who wants to play with it: baillielab.net/trials/km
At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120
Having major withdrawal from #CCR25… Extraordinary event, extraordinary people, in an extraordinary place! @criticalcarereviews.com
CT perfusion and CT angiography did not meet sensitivity and specificity thresholds of 98% to determine death by neurologic criteria (commonly referred to as brain death), a cohort study showed.
www.medpagetoday.com/neurology/ge... #CCR25 #medsky
Did CTP and CTA enhance the diagnosis of death by neurologic criteria in critically ill patients with high accuracy. #FOAMed #POCUS #FOAMcc @criticalcarereviews.com #CCR25
Prehospital hypoxia, hypotension, and hypocarbia were significantly associated with increased risks of death and unfavorable discharge outcomes after TBI.
#CCR25 @criticalcarereviews.com
ja.ma/3FvJdCX
Active life expectancy decreases significantly among older adults with increased hospital admissions for critical illnesses, major nonelective surgeries, and other severe conditions.
#CCR25 @criticalcarereviews.com
ja.ma/3Zm8mqh
Patients with vertebrobasilar artery occlusion who received endovascular thrombectomy beyond 24 hours after symptom onset had a greater increase in the likelihood of good functional status at 3 months.
#CCR25 @criticalcarereviews.com
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It's the final day of #CCR25! 🩺 The JAMA Network Open team has gathered a few more articles to enhance your takeaways from the meeting: 📚 👇
Preoperative use of GLP-1 receptor agonists was not associated with increased risk of postoperative aspiration pneumonia. ja.ma/4dS3mj3
From JAMA Neurology: CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.
#CCR25 @criticalcarereviews.com
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Editorial: The UK-ROX trial demonstrates that targeting lower oxygen saturation in critically ill patients is safe but does not improve outcomes.
#CCR25 @criticalcarereviews.com
ja.ma/3FxWhYu
Conservative oxygen therapy with a target SpO2 of 90% did not reduce 90-day all-cause mortality compared to usual oxygen therapy in mechanically ventilated adult patients.
#CCR25 @criticalcarereviews.com
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📢 #CCR25 Highlights: We've compiled the JAMA and JAMA Neurology papers presented at this year’s meeting. Explore the thread! 👇
Augmenting enteral protein did not improve outcomes for critically ill patients compared with standard protein levels in the intensive care setting. ja.ma/4dV8SkX
INDEX trial: CT perfusion wasn't adequate for evaluating brain death.
huge problem: they're using clinical exam as the gold standard
I think most patients classified as brain dead by CT perfusion but alive by exam were dead... #1/2
#EMIMCC #CCR25
🎙️In this podcast episode, Deputy Editors Linda Brubaker and Preeti Malani and Associate Editor Christopher Seymour discuss the latest science published in JAMA:
➡️ JAMA at #CCR25
➡️ Intrapartum Sildenafil and Perinatal Outcomes
➡️ Trauma-Informed Care; and more.
edhub.ama-assn.org/jn-learning/...
The North American ventilation trials have great control arm protocols. I direct my residents to read them. (Again this is not why the interventions in those trials fail.) #CCR25
PROMIZING trial: PAV+ equivalent to PSV for weaning
Although neutral, I love this trial 😍
shows that PSV is a good weaning mode that optimizes synchrony while providing adequate support (with driving pressure ~12 cm)
🔑 keep PSV in mind as a *maintenance* mode (not just for SBTs)
#EMIMCC #CCR25
INdex Trial Results, coming up at Critical Care Reviews in Belfast! Watch at 10:20AM Eastern for those tuning in from Canada. Free livestream: criticalcarereviews.com #CCR25
A good control arm is not a valid criticism of a trial. #CCR25
PROMIZING Trial Results presented at #CCR25 in Belfast. Congrats to Dr Karen Bosma and the PROMIZING team. See the full trial results in @nejm.org
Also in multiple septic patients, muscle/end tissue biopsies actually show adequate oxygenation but low ATP - shock is as much of a cellular state as a perfusion crisis and do we even need to perfuse “shocked” cells? #emimcc #CCR25
For the vast majority of patients in ITU, weaning isn't a problem. It's always going to be difficult to find a superior weaning strategy in an unselected population. #CCR25
PROMIZING RCT@ccctg.bsky.social @criticalcarereviews.com #CCR25
A graph showing the cumulative probability of successful liberation from ventilation and of death before successful liberation.
In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67
@criticalcarereviews.com #CCR25
#PROMIZINGtrial results are in - no difference in time to successful liberation from mechanical ventilation between proportional-assist ventilation and pressure support ventilation
#CCR25
Post Image
PRINCE trial - remote ischemic preconditioning's impact on myocardial injury in noncardiac surgery patients. #FOAMed #POCUS #FOAMcc #CCR25 @criticalcarereviews.com
https://criticalcarenorthampton.com/2025/06/13/29099/
