Gold nanoparticles prevent the establishment of severe malaria in a murine animal model - Journal of Pharmaceutical Investigation Purpose Malaria is a parasitic disease associated with morbidity and mortality. Severe disease, characterized by the manifestation of different pathologies, is usually associated with Plasmodium falci...

In my latest work, we show that gold nanoparticles prevent the establishment of severe malaria in a murine model, modulating inflammation and multi-organ injury.

Could nanotechnology change how we approach severe malaria?

#Malaria #CerebralMalaria #Nanotechnology #GoldNanoparticles #AKI

🚨 STOP IGNORING THE BRAIN IN PEDIATRIC SHOCK.
You don’t need ICP monitors to save brains. You need 4 minutes and Doppler. ⏱️📡

#NeuroPOCUS #TCD #CriticalCare #PediatricICU #GlobalHealth #CerebralMalaria #BrainPerfusion #PatientSafety #FOAMed #ResourceLimitedSettings #SaveTheBrain

#Medsky🧪 #IDsky #immunosky #Neurosky #publichealth #Plasmodiumfalciparum accumulation at BBB is a hallmark of #cerebralmalaria complication. This occurs when the immune response triggered by parasite-activated leukocytes causes breakdown of BBB in CM ➡️ vascular injury in the absence of iRBC .

High-throughput microfluidic 3D Microvessel On A Chip models #CerebralMalaria
φ100 μm
Collagen hydrogel
👤🧠Endothelial Cell+Pericyte

P. falciparum-infected RBC egress product▶️
⏬Pericyte processes
⏫Permeability
Rescued by Angpt1 or AKB-9778 (Tie2.a)

#EmboMolMed 2025
www.embopress.org/doi/full/10....

#SpatialTranscriptomics Visium #CerebralMalaria

🐭+P.berghei ANKA -/+Artesunate

SPATA spatial trajectory inference of EC-rich spots in infected🧠▶️
⏫EC antigen processing/presentation + leukocyte adhesion
⏬BBB
Partially corrected by Artesunate

#NatureComms 2025
www.nature.com/articles/s41...