Recent Advances in Cytochrome P450 Engineering

📢 Biocatalysis and Biotransformation Congress 2026

🗓️ October 21–22, 2026

📍 San Francisco, California, USA

🏢 Organized by Sciinov Group

#Biocatalysis #Biotransformation #CytochromeP450

#EnzymeEngineering #DirectedEvolution #GreenChemistry

#FruitRes
Researchers identify 28 cytochrome P450 genes in apple, with MdCYP86A21 enhancing drought & salt stress tolerance, offering a key target for breeding resilient crops.
Details: maxapress.com/article/doi/10.48130/fru...
#Apple #CytochromeP450

Full-length structure of CPR-containing self-sufficient cytochrome P450
C.-C., Chen et al.
Paper
Details
#CytochromeP450 #CPR #Biochemistry

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery.
Aubrey, W. et al.
Paper
Details
#Schistosomiasis #CytochromeP450 #DrugDiscovery

U01.05.010 Types of drug interactions Match each drug combination or pharmacologic example with its correct interaction type. Focus on the relationship between the agents — whether their combined effects are additive, synergistic, permissive, antagonistic, potentiating, or lead to tachyphylaxis. Understanding these interaction types is essential for pharmacology exams and clinical applications.

Drug interactions may alter metabolism or receptor effects, impacting efficacy and safety. #DrugInteractions #Pharmacology #Pharmacokinetics #Pharmacodynamics #CytochromeP450 #DrugSafety #ClinicalPharmacology #USMLE #MedicalEducation

U01.05.004 Drug metabolism Carefully review each biochemical reaction and classify it based on its role in drug metabolism. Remember: Phase I reactions introduce or expose functional groups (increasing polarity), while Phase II reactions involve conjugation with endogenous substrates to enhance excretion. Match each reaction type accordingly to strengthen your pharmacology fundamentals.

Drug metabolism modifies drugs via Phase I and II liver reactions to aid detoxification and excretion. #DrugMetabolism #CytochromeP450 #Pharmacokinetics #PhaseI #PhaseII #Pharmacology #Liver #DrugExcretion #MedicalEducation #USMLE

The reduced unit-cell dimensions of cryo crystals of statin-bound CYP105A1 resulted in increased symmetry interactions, which induced cis–trans conversion of the C-terminal peptide bond of Pro142 #CYP105A1 #CytochromeP450 #Statins doi.org/10.1107/S205...

Online now - the Spotlight "Upcycling #lignin with a controlled burn" from Jennifer DuBois.

#CYPenzymes #CytochromeP450 #Biocatalysis #Bioreactor

Read it here: authors.elsevier.com/a/1lFS93S6Gf...

24th International Conference on Cytochrome P450

24th ICCP450 meeting June to 4th July 2025 30 at @unibe.ch is being generously supported by a grant to @pandeylab.bsky.social by 🙏
@snsf.ch #SNSF #Switzerland. 🌍Join us in Bern. Register: iccp450bern.unibe.ch #Science #Heme #CytochromeP450 #P450

Here's the expanded CYP-ADRs dataset on adverse drug reactions for cytochrome P450 substrates (drugs) with ideas behind this work.

Dataset: github.com/jhylin/Adver...

Ideas: jhylin.github.io/Data_in_life...

#prescription_drugs #cytochromep450 #adverse_reactions #cheminformatics

🐻 Get ready, #P450 peeps! for guru David (aka @p450nelson.bsky.social )! #ICCP450! 🎉 He literally wrote the book (well, the website!) on P450 nomenclature 🧬 – foundational work on drug metabolism, toxicology genomics! 🗓️ #P450 #CytochromeP450 #DrugMetabolism #Pharmacology 🔬 www.iccp450bern.unibe.ch

📢 Get ready to hear Prof. Steve Sligar at 24th #ICCP450 meeting in #Bern, #Switzerland! 🇨🇭🗓️ 🎉
🔬✨ Don't miss the chance to learn from a true leader in #cytochromeP450 !
➡️ info: iccp450bern.unibe.ch
See you in Bern! 👋 #DrugMetabolism #Biochemistry #Science #P450 🧪🧬

Grapefruit Is One of the Weirdest Fruits on the Planet From its name, to its hazy origins, to its drug interactions, there's a lot going on beneath that thick rind.

“#Grapefruit has a high volume of compounds called #furanocoumarins, which are designed to protect the fruit from fungal infections. When u ingest grapefruit, those furanocoumarins take your #cytochromeP450 #enzymes offline": https://buff.ly/3WC8lNp #medications