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Structural basis for substrate-dependent allostery in oxygen activation by a cytochrome P450 enzyme revealed by analysis at different temperatures Cytochrome P450 (CYP) enzymes are ubiquitous and important monooxygenases whose archetypal reaction is to insert an oxygen atom from dioxygen into unactivated carbon–hydrogen bonds. They require the orchestrated delivery of electrons as well as protons from the solvent. The latter is controlled through an “acid–alc

#allostery in a #P450 enzyme investigated by variable temperature crystallography and md simulations…. pubs.rsc.org/en/content/a...

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A color photo of a length of residential street in which the asphalt was laid pretty straight but the double center line is anything but.

A color photo of a length of residential street in which the asphalt was laid pretty straight but the double center line is anything but.

Alright road crew, never drink while driving a paint striping truck.

📷 Pentax K-70
🔘 Pentax 55-300mm APS-C

#Photography #Art #Suburban #Suburb #VanishingPoint #Street #Road #Asphalt #Residential #EastCoastKin #BlueSkyArtShow #StreetPhotography #PhotographersOfBlueSky #PhotoOfTheDay #Pentax #P450

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Latest work for researchers in #CH bond activation using an engineered #P450 #enzyme #biocatalyst. Excellent work from all.

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Great resource!
Exploring #P450 superfamily diversity with P450Atlas - Online tool for automated subfamily assignment
onlinelibrary.wiley.com/doi/full/10....

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Repurposing haemoproteins for asymmetric metal-catalysed H atom transfer - Nature Cytochrome P450 enzymes can be repurposed to catalyse asymmetric metal–hydride hydrogen atom transfer, a new-to-nature reaction.

Fantastic work by the Ward lab to repurpose cytochrome #P450 enzymes for a new-to-nature asymmetric metal-catalysed H atom transfer! Just released
@Nature
: doi.org/10.1038/s415.... A must read!🧪

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📣 Check out the Program for 24th ICCP450 meeting 📣
lnkd.in/eei79-2y
www.ICCP450Bern.Unibe.ch
Leading experts in #P450 research from across the world are gathering in beautiful Bern from 30th June to 4th July 2025!!

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Characterisation of the thermophilic P450 CYP116B305 identified using metagenomics-derived sequence data from an Australian hot spring - Applied Microbiology and Biotechnology Abstract Cytochrome P450 enzymes (P450s) have gained significant attention due to their remarkable ability to oxidise unactivated C-H bonds with high regio- and stereoselectivity. Their industrial uti...

New paper investigating a new #biocatalyst from a #metagenome
Characterisation of the #thermophilic #P450 CYP116B305 identified using metagenomics-derived sequence data from an Australian hot spring. Appl Microbiol Biotechnol 109, 133 (2025). doi.org/10.1007/s002...

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24th International Conference on Cytochrome P450

24th ICCP450 meeting June to 4th July 2025 30 at @unibe.ch is being generously supported by a grant to @pandeylab.bsky.social by 🙏
@snsf.ch #SNSF #Switzerland. 🌍Join us in Bern. Register: iccp450bern.unibe.ch #Science #Heme #CytochromeP450 #P450

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Evolutionary insights into the selectivity of sterol oxidising cytochrome P450 enzymes based on ancestral sequence reconstruction. The cytochrome P450 (CYP) enzyme CYP125A1 is a crucial enzyme for the long-term survival and pathogenicity of Mycobacterium tuberculosis. CYP125 genes are found not only in pathogenic mycobacteria but...

New paper in chemical science on #p450 #sterol oxidation.
@chemicalscience.rsc.org

doi.org/10.1039/D5SC...

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Gene fusion and functional diversification of #P450 genes facilitate thermophilic fungal adaptation to temperature change
doi.org/10.1080/2150...
@tandfresearch.bsky.social

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A pretty protein structure made mostly of beta-sheets. There are two hemes, one per monomer. In P460, the heme is linked to a lysine residue and can do hydroxylamine oxidation. In one c prime beta, the heme has peroxidase-like activity. In another,it does gas binding.

A pretty protein structure made mostly of beta-sheets. There are two hemes, one per monomer. In P460, the heme is linked to a lysine residue and can do hydroxylamine oxidation. In one c prime beta, the heme has peroxidase-like activity. In another,it does gas binding.

I'm particularly interested in how these properties in cytochromes P460 are affected by the unusual heme-protein crosslinking. This makes them green, distorts the heme and allows them to oxidise the iron-bound NH2OH to N2O, a greenhouse gas. This is basically what makes them #P460 instead of #P450!

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🐻 Get ready, #P450 peeps! for guru David (aka @p450nelson.bsky.social )! #ICCP450! 🎉 He literally wrote the book (well, the website!) on P450 nomenclature 🧬 – foundational work on drug metabolism, toxicology genomics! 🗓️ #P450 #CytochromeP450 #DrugMetabolism #Pharmacology 🔬 www.iccp450bern.unibe.ch

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24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

1 1 0 0
Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

0 0 0 0
Preview
24th International Conference on Cytochrome P450

Check out 24th International Conference on Cytochrome P450 #ICCP450 to present your #P450 #Research:
www.iccp450bern.unibe.ch
organized by @pandeylab.bsky.social of @unibern.bsky.social

Leading #P450 researchers from across the world will present their latest work at this meeting.

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