A working model of CK2-mediated SF3B3 phosphorylation in promoting ESCC progression. In ESCC, aberrantly activated CK2 phosphorylates SF3B3 at Thr1200, enhancing its interaction with the deubiquitinase USP7. This interaction leads to deubiquitination and stabilization of SF3B3, ultimately promoting a large cohort of alternative splicing events, including the inclusion of exon 4 in EXOSC2, and thereby driving ESCC progression. Targeting both CK2 and USP7, either individually or in combination, using CX-4945 and P5091, respectively, effectively suppresses ESCC progression.

Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @plosbiology.org 🧪 plos.io/4tjuKgI

A working model of CK2-mediated SF3B3 phosphorylation in promoting ESCC progression. In ESCC, aberrantly activated CK2 phosphorylates SF3B3 at Thr1200, enhancing its interaction with the deubiquitinase USP7. This interaction leads to deubiquitination and stabilization of SF3B3, ultimately promoting a large cohort of alternative splicing events, including the inclusion of exon 4 in EXOSC2, and thereby driving ESCC progression. Targeting both CK2 and USP7, either individually or in combination, using CX-4945 and P5091, respectively, effectively suppresses ESCC progression.

Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @plosbiology.org 🧪 plos.io/4tjuKgI

A working model of CK2-mediated SF3B3 phosphorylation in promoting ESCC progression. In ESCC, aberrantly activated CK2 phosphorylates SF3B3 at Thr1200, enhancing its interaction with the deubiquitinase USP7. This interaction leads to deubiquitination and stabilization of SF3B3, ultimately promoting a large cohort of alternative splicing events, including the inclusion of exon 4 in EXOSC2, and thereby driving ESCC progression. Targeting both CK2 and USP7, either individually or in combination, using CX-4945 and P5091, respectively, effectively suppresses ESCC progression.

Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @plosbiology.org 🧪 plos.io/4tjuKgI

STAMBP drives colorectal cancer progression via CXCR4 deubiquitination and bone marrow-derived suppressor cell recruitment - Genes & Immunity Genes & Immunity - STAMBP drives colorectal cancer progression via CXCR4 deubiquitination and bone marrow-derived suppressor cell recruitment

🌅 #Research #Alert
STAMBP drives #colorectal #cancer progression via CXCR4 #deubiquitination and #bone #marrow-derived #suppressor cell #recruitment

@springernature.com #Genes & #Immunity
www.nature.com/articles/s41...

This review summarizes the #Ubiquitination & #Deubiquitination mechanisms, exploring their signaling crosstalk and multilayered regulatory functions in health & disease, while highlighting the clinical potential of their therapeutic targeting.

#OpenAccess: doi.org/10.1038/s413...

Exploring the role of #Ubiquitination & #Deubiquitination in regulating #TumorCells, #ImmuneCells, & non-immune cells within the #TumorMicroenvironment, while discussing the prospect of ubiquitin-related enzyme inhibitors for #CancerTherapy.

#OpenAccess: doi.org/10.1016/j.ge...

Pharmacological inhibition of Ubiquitin-Specific Peptidase 10 (USP10) with spautin-1 attenuates adipogenesis through CCAAT/Enhancer-Binding Protein Beta (C/EBPβ) destabilization - Molecular Biomedicin... The pharmacological control of lipid accumulation in white adipose tissue (WAT) is a key area of focus in obesity research, yet the role of deubiquitination in adipocyte lipid storage remains underexp...

#Research
#Pharmacological inhibition of Ubiquitin-Specific Peptidase 10 (#USP10) with spautin-1 attenuates adipogenesis through CCAAT/Enhancer-Binding Protein Beta (C/EBPβ) destabilization doi.org/10.1186/s435...

#Spautin_1 #Adipogenesis #LipidAccumulation #Deubiquitination

Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3 - Molecular Biomedicine The deubiquitinase ubiquitin-specific protease 13 (USP13) has been implicated in various cancers, yet its precise molecular function and clinical significance in colorectal cancer (CRC) remain poorly ...

#Research
Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3 doi.org/10.1186/s435...

#ColorectalCancer #USP13 #MKK3 #P38 #MAPK #signaling #Deubiquitination #TumorProgression

This review examines the regulatory roles of #Ubiquitination and #Deubiquitination in the #TumorMicroenvironment and discusses the potential of targeting ubiquity-related #Enzymes for #CancerTherapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...