Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes–induced glucose intolerance in offspring TET-controlled GABA-somatostatin signaling in pancreatic islets underlies intrauterine hyperglycemia-induced glucose intolerance in offspring.

Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational #diabetes induced glucose intolerance in offspring #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social www.science.org/doi/10.1126/...

#DOHaD science shows health is shaped before birth, by the environments, policies, and conditions we build today. Food systems, housing, air, and social supports leave biological marks for generations to come. #FutureGenerationsDay
#DOHaDCanada #EarlyLife #Epigenetics #PublicHealth

Health is shaped before birth, by environment, nutrition, stress, and experience.  What we do now leaves biological marks that can carry forward across generations. That’s the science of #DOHaD

Dr. Eunice Lobo, Senior Research Associate at PHFI; Secretary & Strategic Partnerships Lead for the Developmental Origins of Health and Disease (DOHaD) India Regional Society, will present "Early years matter: Contextual factors shaping caregiving and child development in urban poor neighbourhoods of Bangalore, India" on Tuesday, March 17th at 8:00 EDT (12:00 GMT; 14:00 SAST; 17:30 IST; 20:00 CST). Click the link for more information and the Zoom link: https://helti-hub.tghn.org/helti-webinars/

Join us on Tue, Mar 17, 2026 at 08:00 EDT for HeLTI ECR seminar series. Dr. Eunice Lobo will present "Early years matter: Contextual factors shaping caregiving and child development in urban poor neighbourhoods of Bangalore, India." helti-hub.tghn.org/helti-webina...
#DOHaD #EuniceLobo #India #PHFI

Happy #InternationalWomensDay Check out our webpage to learn more about Ethel Margaret Burnside who in the early 20th century was a pioneers of #DOHaD research on early life health and infant development: www.dohad.ca

Kids who eat fewer ultraprocessed foods as toddlers may have better #MentalHealth in later childhood, according to new CHILD research led by @KozetaMiliku @MeaghanKavanag1 in @JAMANetworkOpen @UofT @McMasterU #DOHaD #NutritionMonth

More: childcohort.ca/upf-behaviou...

Today is World Obesity Day

📈This year’s theme specifically highlights how health in 👦🏼 early life, including child obesity, sets a lifelong trajectory of risk for non-communicable diseases. #DOHaD
@dohadcanada.bsky.social

Learn more here www.worldobesityday.org
and our work 👇🏻

#DOHaD Canada is excited to feature Richard Pilsner from Wayne State University as keynote speaker about how environmental exposures affect sperm epigenetics, male fertility and offspring health, including novel reproductive biomarkers at our upcoming meeting @westernuresearch.bsky.social

Preprint: Maternal #obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling #DOHaD www.biorxiv.org/content/10.6...

Maternal GLP-1 receptor activation inhibits fetal growth @apspublications.bsky.social @dream-diabetes.bsky.social #diabetes #DOHaD journals.physiology.org/doi/full/10....

ZFP57 is a regulator of postnatal growth and life-long health - Nature Communications Lactation is essential, but its genetic and epigenetic regulation is poorly understood. Here, Hanin et al. show that ZFP57 has an imprinting-independent role in controlling postnatal nutritional suppo...

🎉 After a very long one (appropriately…), I’m excited to share work revealing an unexpected role for the epigenetic regulator ZFP57 - linking development, lactation, milk composition and lifelong health.

Check it out: www.nature.com/articles/s41...
#MammaryGlandBiology #DOHaD

REVIEW: Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease #DOHaD @apspublications.bsky.social @dohadcanada.bsky.social journals.physiology.org/doi/full/10....

👏🏻 Congrats to @verndolinsky.bsky.social on his End Diabetes award from #Diabetes Canada!!

🤰🏻Critical gestational diabetes research that aims to improve blood sugar levels during #pregnancy through a novel intervention strategy.

#DOHaD
@dohadcanada.bsky.social

Congratulations!!! This is really important research!!
🎉🎉
#DOHaD

[5/5] Next steps: Future studies are needed to examine potential underlying causes of the observed associations between vitamin D and ASD-related traits, and the sex specificity of the found associations.

#DevPsych #VitaminD #ASD #DOHaD

🧪

The Impact of Maternal High‐Fat Diet on Stem Cell Programming and Disease Susceptibility in Offspring This graphical abstract illustrates that a maternal high-fat diet alters fetal epigenetics, gut microbiota, and molecular and metabolic pathways, thereby disrupting stem cell programming and increasi...

REVIEW: The Impact of Maternal High‐Fat Diet on Stem Cell Programming and Disease Susceptibility in Offspring - Molecular Nutrition & Food Research #DOHaD @Dohadcanada onlinelibrary.wiley.com/doi/abs/10.1...

Maternal #obesity damages blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers @apspublications.bsky.social @dohadcanada.bsky.social #DOHaD journals.physiology.org/doi/full/10....

Undernourishment - the root of
🩸Type 5 #Diabetes 🩸
Now officially recognised by the International Diabetes Federation

& what we in the developmental origins of health & disease #DOHaD & early life nutrition fields have known for decades

www.sciencealert.com/a-distinct-n...

Key takeaway: Earlier and longer exposure (type 2 diabetes) vs later exposure (gestational #diabetes) leaves a different epigenetic footprint and highlights #pregnancy as a critical window that defines future disease risk #DOHaD #MaternalHealth @dohadcanada.bsky.social

In-utero exposure to maternal diabetes and DNA methylation alterations in the Next Generation birth cohort - Clinical Epigenetics Introduction The incidence of type 2 diabetes (T2D) in youth is increasing and in-utero exposure to maternal diabetes is a known risk factor, with higher risk associated with pregestational T2D exposu...

How does the timing of in utero exposure to maternal #diabetes shape offspring health risk? This paper from the Next Generation birth cohort (n=210) explores this question @dream-diabetes.bsky.social @meaghanjones.bsky.social #DOHaD
link.springer.com/article/10.1...

BMC Journals | Open access, community-focused BMC is a leader in open access publishing, driving progress in the life sciences, health sciences, medicine and applied sciences.

🧵 1/7 From @dream-diabetes.bsky.social and the Next Generation cohort study: Differential effects of type 2 #diabetes and gestational diabetes on maternal and cord blood adipokines and newborn weight #DOHaD @dohadcanada.bsky.social rdcu.be/eQ0e2

🧬🍽️ Your macrophages may be carrying your mother’s metabolic history!
In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming

Call for Abstracts ENDO 2026 Call for Abstracts

Greetings from the US DOHaD Society! We’re excited to share:
• Welcome to the new 2026-2028 Council: www.usdohad.org/leadership/
• ENDO 2026 abstracts are open (deadline Jan 15): bit.ly/3XBmM4A
• Interested in a US DOHaD Meet-Up at ENDO? Let us know: bit.ly/4pmqA61
#DOHaD #USDOHaD #ENDO2026

a lion standing on top of a rock with the words " the circle of life " below him ALT: a lion standing on top of a rock with the words " the circle of life " below him

It was one of the first #DOHaD courses in 🇨🇦—been teaching it for 10 yrs
4/n

There are 40 seats left for @humanmilkinstitute.bsky.social #HMI26 symposium!

Early bird reg ends 📅 THIS SATURDAY!! 📅

🔗 tinyurl.com/hmi26r

🧪🩺🛟 #MedSky #PedSky #Breastfeeding #HumanMilk #NABBLM #IBCLC #PublicHealth #MaternalHealth #MCH #DOHaD #ChildHealth #InfantNutrition #PublicHealth #MedEd

Maternal Obesity Programs Glucose Intolerance in Pregnant Female Offspring Maternal obesity is a known risk factor for metabolic dysfunction in offspring; however, its effect on metabolism during pregnancy in female offspring rema

Maternal #Obesity Programs Transgenerational Glucose Intolerance in Pregnant Female Offspring #DOHaD #diabetes @dream-diabetes.bsky.social diabetesjournals.org/diabetes/art...

Don't miss the DOHaD Canada Trainee Tuesday webinar by Zeyu Li, John Hopkins School of Public Health @usdohad.bsky.social
"Early Exposures, Lifelong Consequences: Gestational Exposure to Forever Chemicals (PFAS) and Child Health" #DOHaD November 18 2PM CST Zoom meeting details below

Association of Maternal Prepregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood Objective This study aimed to evaluate associations of maternal prepregnancy BMI with offspring BMI and blood pressure in childhood, specifically for infants born preterm. Methods In this observat...

From the ECHO Cohort Study (n=13,810) Association of Maternal Pre- #pregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood #DOHaD #obesity @dream-diabetes.bsky.social @dohadcanada.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

International Day for the Eradication of Poverty | Reboot Education Taking place on 17th October every year. Raising awareness of the need to eradicate poverty.

oday is International Day for the Eradication of Poverty. Poverty affects health across generations. Let’s build a fairer future through research, compassion & action. 💛 Learn more: education.rebootthefuture.org/calendar/int...
#DOHaD #EndPoverty #GlobalSolidarity #ECRs

If you’re a #HumanMilk / #breastfeeding researcher/clinician and you want to bust through the media noise and bias towards “women’s issues,” we’ve got you:

bsky.app/profile/brid...

🧪 🩺 🛟 #SciComm #MedEd #MCH #MaternalChildHealth #ChildHealth #DOHaD #OBSky #PedSky #pediatrician