Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation

This study shows that inhibiting miR 144 5p alleviates #Doxorubicin induced #HeartFailure by targeting ACSM1 and reducing #LipidPeroxidation, suggesting the miR 144 5p/ACSM1 axis as a novel #therapeutic target. #medsky #HeartFailure #Cardiotoxicity

Full article here: doi.org/10.1007/s115...

Bacterial strain breaks decades-old bottleneck in chemotherapy drug manufacturing An international team of researchers has achieved a breakthrough in the production of doxorubicin, a vital chemotherapy agent. The study identifies and resolves molecular "bottlenecks" that have…

#Bacterial strain breaks decades-old bottleneck in #chemotherapy #drug manufacturing ...

| #bacteria | #biotech | #doxorubicin | #medicines | Via @sciencex.bsky.social

"This study was selected as Editor's Choice for its mechanistic depth and translational relevance. #Doxorubicin remains a cornerstone of #breast #cancer chemotherapy, yet the contribution of lysosome membrane permeabilization to its cytotoxic effect...

New study uses cross-modal integration of #metabolomics and cardiac functionality to capture dynamic metabotoxic effects of #doxorubicin in engineered heart tissues. #heartonchip #cardiotoxicity https://ow.ly/HfsS50XC6NI

ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press

Dihydroartemisinin May Enhance Antitumor Activity of Doxorubicin in HCC In preclinical cell and animal models, DHA and DOX were effective against HCC progression, and their combined use amplified these effects.

An antimalarial drug, #Dihydroartemisinin (DHA), may restore antitumor activity of #Doxorubicin (DOX) in patients with #HepatocellularCarcinoma (HCC) with DOX resistance. Published in Digestive Diseases and Sciences.

Read more: https://bit.ly/48cAjVf

#RareDisease #MedSky

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response - Scientific Reports Scientific Reports - Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

www.nature.com/articles/sre...

"and in vivo inhibitor of XBP1 (X-Box Binding Protein 1) activation, a previously unknown activity for this widely utilized cancer chemotherapeutic drug." #Doxorubicin

NUS Develops Non-Invasive Magnetic Treatment to Enhance Chemotherapy for Breast Cancer Researchers at the National University of Singapore have pioneered a magnetic field therapy that enhances chemotherapy effectiveness for breast cancer treatment, minimizing side effects.

NUS Develops Non-Invasive Magnetic Treatment to Enhance Chemotherapy for Breast Cancer #Singapore #cancer_therapy #NUS #Doxorubicin

Human and canine osteosarcoma cell lines: How do they react upon incubation with calcium phosphate-coated lipid nanoparticles carrying doxorubicin and curcumin? Osteosarcoma (OSA) is a bone cancer that affects both humans and animals, with dogs being particularly vulnerable. Standard therapy is often limited b…

Human and canine #osteosarcoma cell lines: How do they react upon incubation with calcium phosphate-coated lipid nanoparticles carrying #doxorubicin and curcumin? www.sciencedirect.com/science/arti...

Doxorubicin - Wikipedia

Doxorubicin is a chemotherapy drug nicknamed “red devil” and “red death” on account of its ruby-red color and toxic side effects. It was first synthesized using bacteria discovered in the soil around an Italian castle. #history #medicine #doxorubicin #biotech