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#Endolysin #Probiotics #microbiome #Listeria

Why do #phages make short #endolysin isoforms? 🧬🦠 Dunne team in @ethz.ch, using Staph φ2638A, reveals both full-length and short variants form heterodimers to boost lysis & phage release—explaining conserved internalTSSs in phage genomes!
buff.ly/1I0H9ya

The novel Poseidoniales virus, Adrikavirales become more interesting. This genome encoded which could be novel archeal-like #holins. Additionally, LytA-like (N-acetyl muramoyl L-alanine amidase) #endolysin was found adjacent to these holins, possibly aiding in viral #egress (see Fig 7).

improved #bovine #mastitis treatment using designer #endolysin in #streptococcus uberis #mouse model
#Researchpaper with E. Meyer in @SpringerMicBio :
bit.ly/LysinMastitis

#antibiotic #bacteria #infectious #disease #sustainable #agriculture
#phage #protein #engineering