Released a #Preprint on #Bacteriophage #Endolysins: while monotherapy shows promise, it’s not always consistent. I argue for combining endolysins with cell wall–targeting #Antibiotics to improve future clinical outcomes. Feedback appreciated!
dx.doi.org/10.31219/osf...
Knowledge thrives through challenge – and Cernooka et al. challenge our traditional view of #bacteriophage #endolysins. Read all about the new class of C-terminal anchor endolysins:
➡️ doi.org/10.1002/1873-3468.70042
#microbiology #enzymes
The genomes encoded phosphoesterase, which could be involved in membrane destabilisation. These #holin #endolysins systems need further investigations of course (culturing/transcriptomics), since mixed membranes of their Poseidoniales host that likely contain bacterial/eukaryotic G3P backbones.
