Research priorities in epilepsy: a consensus position paper from the European Reference Network ERN EpiCARE.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Epilepsy #ERN #EpiCARE #EU4Health #HealthUnion #genetics #rareandcomplexepilepsies #researchfunding @stephane_auvin

Patients receiving PER MT were more likely to achieve seizure freedom but had a higher incidence of dizziness than those receiving LEV MT.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Chinesepatients #focalonsetseizures #Levetiracetam #Perampanel #monotherapy #seizurefreedomrate

This case shows the potential of SqEEG to guide treatment decisions in the perioperative setting.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #epilepsysurgery #epilepsytreatment #objectiveseizuredocumentation #subcutaneousEEG #ultralongtermEEGmonitoring

URE patients had a median of six failed treatment strategies, including surgery or neurostimulation.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #drugresistantepilepsy #neurostimulation #resectivebrainsurgery #ultrarefractoryepilepsy

In the cavernous sinus, eEEG detected IEDs with higher amplitude than scalp EEG, indicating its diagnostic potential.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #EP01 #focalonsetepilepsy #localizedepileptogenicity

Introducing a systematic sample handling protocol to assess tissue epileptogenicity at structural, functional and molecular levels.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #electronmicroscopy #electrophysiology #histology #MRI #multiscale #omics

The overall pooled prevalence of active cases of IESS was 3.33 per 100 000 population (95% CI, 1.46–5.82) in India.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #burden #infantilespasms #prevalence

Dravet Syndrome is now diagnosed earlier but this has not led to earlier initiation of stiripentol treatment.⁠
doi.org/10.1002/epi4...
⁠
#epilepsy #ILAE #epilepsiaopen #efficacy #healthcareutilization #qualityoflife #statusepilepticus #stiripentol #DravetSyndrome⁠

The ELUCID Study is a prospective, multi-site, longitudinal observational study on late-onset unexplained epilepsy (LoUE).
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #cognition #dementia #elderly #lateonset

New in Epilepsia Open – December 7, 2025
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#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

Martinique status epilepticus incidence: 25.2/100000—ourfold higher than mainland France.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #mobileintensivecareunit #mortality #prehospitalcare #statusepilepticus #WestIndies

We performed epilepsy surgery in experimental models of focal onset seizures to investigate the effectiveness of surgeries using neurophysiological and metabolic changes before and after the surgery.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #DBS #kainicacid #kindling

RNS with neocortical depth leads achieved 66.7% seizure reduction at 1 year and 77.5% at long term follow up.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #depthelectrode #neocortex #networkremodeling #responsiveneurostimulation #RNS #seizure #sEEG

This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel

Epilepsy is associated with significantly increased long-term risk of cardiovascular disease.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #cardiovasculardiseases #riskfactors #SouthKorea

This is a pediatric case series of patients suffering from multifocal or generalized drug-resistant epilepsy treated with centromedian RNS.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #centromediannucleus #thalamus #drugresistantepilepsy #pediatric #responsiveneurostimulation

We compared the early adjuvant treatment outcomes of IV lacosamide and levetiracetam for status epilepticus after benzodiazepine use.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #diagnosisprocedurecombination #overlapweighting #propensityscore #seizure

Combined multimodal imaging (82–100% sensitivity) outperforms single modalities for localizing epileptogenic foci in surgical candidates.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #multimodalimaging #neuroimaging #radiosurgery #stereotactic

The study compared the effectiveness of 5 mg melatonin versus partial sleep deprivation in inducing sleep during nap-time EEG in children with epilepsy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #melatonin #napEEG #sleepinduction #sleeplatency

This review provides a practical approach to assessing and selecting PROMs, and discusses how they may be incorporated into clinic workflows.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #mooddisorders #patientreportedoutcome #qualityoflife #seizure

New in Epilepsia Open – November 9, 2025
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#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

Global adolescent epilepsy burden increased 1990–2021, with marked regional and SDI disparities.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #adolescenthealth #globalburdenofdisease #healthpolicy #publichealth

Approximately, 26% patients with unexplained seizures or epilepsy deterioration tested positive for autoimmune or paraneoplastic antibodies.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antibodytesting #APEscore #autoimmuneencephalitis #EEG #paraneoplasticencephalitis

After a median follow-up of 20 months, CBD was globally effective and safe in 107 patients with LGS, DS, TSC, and other DEEs.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #CBD #DEE #Dravetsyndrome #LennoxGastautsyndrome #realworld #cannabidiol

This MR study assessed causal links between thousands of plasma proteins and epilepsy risk.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #causalinference #GWAS #MR #plasmaproteins

The preponderance of evidence indicates that the KD is effective in targeting IESS.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #acidosis #infantileepilepticspasms #ketogenicdiet #microbiome #tryptophan

Serum phosphate measurements are rarely included in the acute evaluation of Transient Loss of Consciousness (TLoC).
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #biomarker #electrolyte #hypophosphatemia #seizure #telemedicine

New in Epilepsia Open – November 1, 2025
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#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

To the editors: SCN1A gain‐of‐function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications Click on the article title to read more.

Letter and Response - Addressing "SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications"

Letter: doi.org/10.1002/epi4...
Authors’ Response: doi.org/10.1002/epi4...
Original Article: doi.org/10.1002/epi4...

#Epilepsiaopen #Epilepsy #ILAE

New in Epilepsia Open – October 26, 2025
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#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch