Nearly Half of Patients With LGS Experience 50% or Greater Seizure Reduction With Perampanel A meta-analysis showed perampanel leads to clinically meaningful seizure reduction in LGS, although with variable durability.

#Perampanel (#Fycompa®) provides clinically meaningful seizure reduction in patients with Lennox‑Gastaut syndrome (#LGS), with 46.5% of patients experiencing at least a 50% reduction in seizure frequency.

Learn more: https://bit.ly/3NnKXlG

#RareDisease #LennoxGastautSyndrome #MedSky

Patients receiving PER MT were more likely to achieve seizure freedom but had a higher incidence of dizziness than those receiving LEV MT.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #Chinesepatients #focalonsetseizures #Levetiracetam #Perampanel #monotherapy #seizurefreedomrate

Acute PHM is a clinically heterogeneous disorder with significant diagnostic and therapeutic challenges and a poor prognosis.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #cardiacarrest #LanceAdamssyndrome #myoclonicstatusepilepticus #perampanel #postanoxicmyoclonus

This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel

A total of 70.3% of patients were seizure-free after 12 months on perampanel monotherapy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #monotherapy #perampanel

Perampanel has a superior efficacy and tolerability in the treatment of children with Dravet syndrome as add-on therapy.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #China #Dravetsyndrome #efficacy #perampanel #SCN1Agene

Perampanel monotherapy in pediatric epilepsy: Emphasizing the need for comprehensive safety evaluation
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ilae #BTRE #insilico #perampanel #safety #toxicology

Key point: Short-term treatment with PER did not result in significant changes in BMD among adults with epilepsy (p > 0.05).
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ilae #bonemetabolism #bonemineraldensity #Perampanel

Els gliomes, a més de créixer dins del cervell, també s’hi connecten, com si en formessin part del mateix circuit i xarxes.

D’altra banda el #Perampanel, un fàrmac antiepilèptic, suprimeix el mateix tipus de receptors que fan servir les cèl·lules de glioma per expandir-se.