This study identifies #Progranulin as a key regulator of #BoneMineralDensity in #PostMenopausalWomen, revealing a positive feedback loop with #estrogen signaling and showing that PGRN loss drives #osteoporosis via ERα degradation.

#OpenAccess: doi.org/10.1016/j.ge...

#Senescence🦴

p21Cip1- versus p16Ink4a-mediated senescence in radiation-induced #Osteoporosis

Ablating p21+ cells partially rescues
#BoneMineralDensity
#MineralAppositionRate
Trabecular architecture
#BoneMarrowAdiposity
in irradiated🐭🦴

#AgingCell 2022
onlinelibrary.wiley.com/doi/10.1111/...

Original Research 🔍

This study explores how #bodymass and its components influence #bonemineraldensity across skeletal sites, offering new insight into the mechanisms behind #bonestrength and #osteoporosis prevention.

👉 Read: zurl.co/jgnvF

Weight Loss-Induced Sex Hormone Changes May Affect BMD Loss in T2D Weight loss-induced sex hormone changes had a mediating effect on bone mineral density loss among patients with type 2 diabetes.

Changes in #BoneMineralDensity were mediated by changes in E2 and testosterone among women and men, respectively, with #T2D undergoing weight loss.

@erinmichos.bsky.social @johnshopkinssph.bsky.social @jhu.edu @imperialcollegeldn.bsky.social @uthsc.bsky.social

Key point: Short-term treatment with PER did not result in significant changes in BMD among adults with epilepsy (p > 0.05).
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ilae #bonemetabolism #bonemineraldensity #Perampanel

Global data highlights effectiveness of romosozumab - PharmaTimes Studies show improved bone mineral density and healthcare cost reductions

#osteoporosis #UCB #romosozumab #clinicalstudies #bonemineraldensity #osteoporosistreatment #osteoporosistreatment #boneformation #boneresorption #WCOIOFESCEO2025 #systematicliteraturereview #realworldevidence #severeosteoporosis #osteoporosismanagement
pharmatimes.com/news/global-...