Case builds for Biogen, Stoke's Dravet syndrome drug Hopes have risen for a new treatment for severe childhood epilepsy Dravet syndrome, on the back of new data for Biogen and Stoke's zorevunersen

#Biogen #Dravetsyndrome #childhoodepilepsy #StokeTherapeutics #zorevunersen #EMPERORtrial #antisenseoligonucleotide #ASO #SCN1Agenemutation #EPNS #Developmentalencephalopathy #epilepticencephalopathy #Dravetsyndromepatients #SUDEP #paediatricneurology
pharmaphorum.com/news/case-bu...

These findings highlight a potential GOF effect for certain DS cases, suggesting that SCB-ASMs may be effective for GOF/mixed DS.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #Dravetsyndrome #epilepticencephalopathy #gainoffunction #SCN1A #sodium channel

Key point: Optogenetics induced excessive neural excitation of the hypothalamus projecting toward the mediodorsal thalamus and prelimbic cortex.
onlinelibrary.wiley.com/doi/full/10....

#epilepsy #ILAE #ablationbasedepilepsysurgery #EEGanalysis #epilepticencephalopathy #epilepticnetwork

Recent research identifies CSMD1 as a causative gene for developmental and epileptic encephalopathy & generalized epilepsies providing new understanding of genetic factors involved in such neurological conditions. #EpilepticEncephalopathy Read more: www.sciencedirect.com/science/arti...