Loss of intestinal sorting nexin 27 disrupts epithelial barrier function and promotes inflammation, identifying SNX27 as a key regulator of gut homeostasis and a potential target in inflammatory disease.
🔗https://ow.ly/AUXi50YrxlC
🏷️ #GutBarrier

🥳 Congratulations, David Tornai et al. from Maria Papp's team at the University of Debrecen! The paper has been viewed more than 625 times since its publication in Dec 2025 & is currently amongst the top-downloaded articles!
#SerumVillin #GutBarrier #ACLF

📰 onlinelibrary.wiley.com/doi/10.1111/...

The mucosal surface is where the host and microbiota shape health or disease 🦠
A balanced microbiota supports immune maturation, while disruption drives inflammation.
🧬2nd Edition: Global Microbiome Congress
📅 June 15–16, 2026 |📍 Boston, USA (Hybrid)
🔗 microbiomecongress.org
#GutBarrier #Immunology

This @bidmcreseach.bsky.social Beth Israel Deaconess Medical Center study offers a compelling mechanistic link between #bingedrinking and early #gutbarrier injury through #immune activation. Short-term behaviors can trigger longer-term inflammatory consequences.
www.linkedin.com/posts/drmelv...

👉 In this video, Dávid Tornai (MD, PhD) from Maria Papp's group at the University of Debrecen in Hungary presents the consortium's research on serum #villin-1, a tell-tale sign of #GutBarrier failure in cirrhotic patients with acute #decompensation via a graphical abstract.

📽️ youtu.be/URerer6AxxY

Serum Villin‐1—A Novel Marker of Gut Barrier Damage in Acutely Decompensated Cirrhosis: A Cohort Study and Validation Serum villin-1 is a non-invasive indicator of gut barrier damage and short-term mortality in acutely decompensated cirrhosis. Incorporating villin-1 assessment into risk stratification methods improv...

👏 New study from Dávid Tornai and colleagues 🎉: Serum #Villin1 is a promising non-invasive marker of #GutBarrier damage in #cirrhosis and #ACLF.

It rises with severity, predicts 90-day mortality, links to #inflammation, and has been validated in an independent cohort!

📜 doi.org/10.1111/apt....

Amazing work by Vishnu & the MechanoGut team! 💩⚙️🛠️ Huge thanks to @cbitoulouse.bsky.social imaging & animal facilities, our dear colleagues and collaborators, and funders @cnrs.fr ATIP-Avenir, ED-BSB, @frm-officiel.bsky.social
#Mechanobiology #GutBarrier #EpithelialBiology #CellAdhesion

🚨 New #LiverFailure insights 🚨

In patients with #cirrhosis + acute #decompensation, secretory #IgA strongly correlates with #gut-barrier failure and is a powerful predictor of 90-day mortality in acute-on-chronic #LiverFailure #ACLF

👉 Watch on YouTube: youtu.be/KapUqG7AFFk

#Biomarkers #GutBarrier

📣 Swing by at our Networking Session here at #EASLCongress in Amsterdam tomorrow - beginning with an introduction by project coordinator Jonel Trebicka, followed by talks on the role of the #virome in #cirrhosis, how #villin-1 + #IgA impact the #GutBarrier function, and of course about the #ALBTrial

📣 Meet the MICROB-PREDICT team during our Networking Session at #EASLCongress to learn more about the virome's role in #cirrhosis, how villin-1 + IgA influence #GutBarrier function, and about the ALB-trial ⚕️

📅 Wednesday 7 May, 14:00-14:30
📍 Cirrhosis & Complications Track Hub

@easlnews.bsky.social

Goblet cells mechanically breach the epithelial barrier in gut homeostasis The intestinal epithelium has to maintain a tight barrier to the harsh luminal environment. The absorptive enterocytes have a polygonal and columnar shape, while mucus-producing goblet cells have a ro...

🔗 Preprint link: www.biorxiv.org/content/10.1...
#mechanobiology #intestinalepithelium #gobletcells #biomechanics #organoids #gutbarrier

Eating ultra-processed foods harms your gut—here’s how inflammation takes hold Ultra-processed foods disrupt gut microbiome balance, causing inflammation, reduced microbial diversity, and increased gut permeability. This microbiome imbalance contributes to chronic diseases inclu...

Eating ultra-processed foods harms your gut—here’s how inflammation takes hold 🥘🦠⚠️ www.news-medical.net/news/2025030... #GutHealth #Microbiome #UltraProcessedFoods #Inflammation #HealthyEating #Nutrition #Wellness #GutBarrier #Diet