Further results from the Exa-cel study.
Focus: CLIMB SCD-121 Trial
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Identification of RUNX + c-Kit + HSPCs in the mouse placental labyrinth. Left: Schematic diagrams of the mouse E12.5 placenta (top) and maternal-fetal vascular arrangement within the labyrinth (bottom) are shown. Red lines indicate fetal blood vessels. EC, fetal endothelial cells; HSPC, hematopoietic stem and progenitor cells; S-TGC, sinusoidal-trophoblast giant cells; SynT-1, syncytiocytotrophoblast layer I; SynT-2, syncytiocytotrophoblast layer II. Right: 3D snapshot view of immunostaining for c-Kit (magenta), RUNX (red), CD34 (green) and DAPI (blue) on 20-μm frozen sections of E12.5 mouse placenta. White arrows indicate placenta HSPCs.
The #placenta has been proposed to harbor hemogenic endothelium that generates #HematopoieticStemCells (HSCs). @zfish24.bsky.social &co test this using lineage tracing analyses, but find no evidence that the placental vasculature is a site of de novo HSC formation 🧪 @plosbiology.org plos.io/4hl3qZF
Identification of RUNX + c-Kit + HSPCs in the mouse placental labyrinth. Left: Schematic diagrams of the mouse E12.5 placenta (top) and maternal-fetal vascular arrangement within the labyrinth (bottom) are shown. Red lines indicate fetal blood vessels. EC, fetal endothelial cells; HSPC, hematopoietic stem and progenitor cells; S-TGC, sinusoidal-trophoblast giant cells; SynT-1, syncytiocytotrophoblast layer I; SynT-2, syncytiocytotrophoblast layer II. Right: 3D snapshot view of immunostaining for c-Kit (magenta), RUNX (red), CD34 (green) and DAPI (blue) on 20-μm frozen sections of E12.5 mouse placenta. White arrows indicate placenta HSPCs.
The #placenta has been proposed to harbor hemogenic endothelium that generates #HematopoieticStemCells (HSCs). @zfish24.bsky.social &co test this using lineage tracing analyses, but find no evidence that the placental vasculature is a site of de novo HSC formation 🧪 @plosbiology.org plos.io/4hl3qZF
Identification of RUNX + c-Kit + HSPCs in the mouse placental labyrinth. Left: Schematic diagrams of the mouse E12.5 placenta (top) and maternal-fetal vascular arrangement within the labyrinth (bottom) are shown. Red lines indicate fetal blood vessels. EC, fetal endothelial cells; HSPC, hematopoietic stem and progenitor cells; S-TGC, sinusoidal-trophoblast giant cells; SynT-1, syncytiocytotrophoblast layer I; SynT-2, syncytiocytotrophoblast layer II. Right: 3D snapshot view of immunostaining for c-Kit (magenta), RUNX (red), CD34 (green) and DAPI (blue) on 20-μm frozen sections of E12.5 mouse placenta. White arrows indicate placenta HSPCs.
The #placenta has been proposed to harbor hemogenic endothelium that generates #HematopoieticStemCells (HSCs). @zfish24.bsky.social &co test this using lineage tracing analyses, but find no evidence that the placental vasculature is a site of de novo HSC formation 🧪 @plosbiology.org plos.io/4hl3qZF
Model for C-Kit–dependent trogocytosis regulates niche retention in blood stem cells. A subset of HSCs (marked by high C-Kit expression) can acquire membrane material from adjacent macrophages through trogocytosis (TROGPos HSC) to augment retention in the bone marrow. Stem cells with low C-Kit expression are mobilized to the peripheral blood.ILLUSTRATION: TATYANA A. HARRIS FROM THE EINSTEIN CREATIVE SERVICES TEAM
#MedSky🧪#Hematopoiesis #Clinicalresearch
#Macrophages and #hematopoieticstemcells teach us that sharing is caring @natureportfolio.bsky.social
rdcu.be/dTV5E
www.science.org/doi/10.1126/...
