🩸Facts about Myelofibrosis:

Specific Strategies for Anemia

#Myelofibrosis #Hematology #Oncology #BloodDisorders #Anemia #ESAtherapy #Danazol #Thalidomide #Lenalidomide #Hepcidin #Erythropoiesis #MedEd #RareDiseases #HEMEHUB

🩸🔬Today’s question!

Swipe to see the answer and its explanation!

#Myelofibrosis #MF #Hematology #HemeOnc #Hepcidin #JAKSTAT #Erythropoiesis #MPN #BloodDisorders #HematologyEducation #MedEd #HemeHub #ClinicalHematology #PatientCare @gmpnsf.bsky.social

🩸Today’s questions!

Swipe to see the answers and their explanations!

#Myelofibrosis #MPN #Hematology #HemeOnc #Ruxolitinib #Selinexor #Pelabresib #JAKInhibitors #Hepcidin #Erythropoiesis #Splenomegaly #BoneMarrow #BloodDisorders #MedEd #ClinicalHematology #MPNResearch #BloodCancer #HEMEHUB

🩸Facts about Myelofibrosis:

JAK Inhibitor Therapy

#Myelofibrosis #MPN #Hematology #JAKInhibitors #Ruxolitinib #Momelotinib #ACVR1 #Hepcidin #Erythropoiesis #Splenomegaly #BoneMarrow #BloodDisorders #ClinicalHematology #MedEd #HemeOnc #HEMEHUB
@gmpnsf.bsky.social @rarediseaseadvisor.bsky.social

-This persistent IFN-I signaling ➡️ to ⏫️ expression of #hepcidin in hepatocytes & specific macrophages (TREM2+)
- Elevated hepcidin impairs the function of the iron exporter ferroportin (SLC40A1-mediated iron excretion),

Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults (1) Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol deficiency has shown to upregulate hepcidin expression in animals, while conflicting evidence links VD status with hepcidin concentration in humans. ...

Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults [2019]
pmc.ncbi.nlm.nih.gov/articles/PMC...

#IronDeficiency #anemia #hepcidin #VitaminA #inflammation #aging

New paper from the @klingmuelab.bsky.social & Timmer labs out in @cp-cellsystems.bsky.social: #Diclofenac & #acetaminophen unexpectedly shape #IL-6 and #hepcidin signaling in #liver cells.
🔗 doi.org/10.1016/j.ce...
👇 Thread with key findings

Kidney hepcidin protects the collecting duct against ferroptosis in ischemia/reperfusion-induced acute kidney injury

doi.org/10.1016/j.kint.2025.05.030

#OpenAccess #NephSky #MedSky #AKI #acutekidneyinjury #hepcidin

Hepcidin Agents Set to Improve Polycythemia Vera Care Protagonist Therapeutics earlier this month reported positive results from its phase III VERIFY study of hepcidin mimetic rusfertide for th...

#Hepcidin agents set to improve #PolycythemiaVera care (blog): rnaitherapeutics.blogspot.com/2025/03/hepc...

$PTGX $SLN $IONS #rusfertide #divesiran #sapablursen

Remember to sign up for this great webinar on bone morphogenetic proteins and iron metabolism!
#BMP2 #BMP6 #ALK2 #ALK3 #iron #hepcidin #SMAD