💭🎯Today’s case-based question!

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#CMML #Hematology #HemeOnc #Anemia #Erythropoietin #ChronicMyelomonocyticLeukemia #BoneMarrowFailure #EPO #Erythropoiesis #BloodDisorders #HemeHub #MedicalEducation #MedEd #ClinicalHematology #HematologyEducation

🩸Facts about Myelofibrosis:

Specific Strategies for Anemia

#Myelofibrosis #Hematology #Oncology #BloodDisorders #Anemia #ESAtherapy #Danazol #Thalidomide #Lenalidomide #Hepcidin #Erythropoiesis #MedEd #RareDiseases #HEMEHUB

🩸🔬Today’s question!

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#Myelofibrosis #MF #Hematology #HemeOnc #Hepcidin #JAKSTAT #Erythropoiesis #MPN #BloodDisorders #HematologyEducation #MedEd #HemeHub #ClinicalHematology #PatientCare @gmpnsf.bsky.social

🩸Today’s questions!

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#Myelofibrosis #MPN #Hematology #HemeOnc #Ruxolitinib #Selinexor #Pelabresib #JAKInhibitors #Hepcidin #Erythropoiesis #Splenomegaly #BoneMarrow #BloodDisorders #MedEd #ClinicalHematology #MPNResearch #BloodCancer #HEMEHUB

🩸Facts about Myelofibrosis:

JAK Inhibitor Therapy

#Myelofibrosis #MPN #Hematology #JAKInhibitors #Ruxolitinib #Momelotinib #ACVR1 #Hepcidin #Erythropoiesis #Splenomegaly #BoneMarrow #BloodDisorders #ClinicalHematology #MedEd #HemeOnc #HEMEHUB
@gmpnsf.bsky.social @rarediseaseadvisor.bsky.social

🩸Facts about Myelofibrosis:

Disease Pathogenesis & Diagnosis

#Myelofibrosis #Hematology #HemeHub #Hepatosplenomegaly #Anemia #MF #JAK2 #CALR #MPL #Erythropoiesis #Inflammation #Pathophysiology #HematologyEducation #MedicalEducation

TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome - EMBO Molecular Medicine Diamond-Blackfan anemia syndrome (DBAS) is marked by defective erythropoiesis caused by impaired ribosome biogenesis and aberrant signaling. Here, we investigate how ribosomal stress-induced activatio...

TKI-mediated inhibition of NLRP1 #inflammasome restores #erythropoiesis in Diamond-Blackfan anemia syndrome 👉 doi.org/10.1038/s443...

By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es

Where are red blood cells produced? #redbloodcells #erythrocytes #erythropoiesis #anatomy ... Continue to: www.youtube.com/watch?v=_p4f...

New findings from Sebastian Stifter, Melanie Greter et al. (University of Zurich) reveal that XPR1 is required for the development, identity, and function of #macrophages involved in #erythropoiesis. rupress.org/jem/article/...

#InnateImmunity #inflammation

Synergistic mechanisms of pleiotropic cytokines and lineage-specific factors. IL-17A dramatically enhances erythropoiesis, increasing the production of ProE precursors above levels generated by Epo alone. HSC, hematopoietic stem cell; MPP, multipotent progenitor; EBMP, erythroid/basophil-mast cell/megakaryocytic progenitor; BFU-E, erythroid burst-forming unit; CFU-E, erythroid colony-forming unit; ProE, pro-erythroblast; BasoE, basophilic erythroblast; PolyE, poly erythroblast; OrthoE, ortho-chromatic erythroblast; RBC, red blood cell. Created in BioRender. Wilson, N. (2025).

What underlies the dynamics of #RedBloodCell production? Nicola Wilson explores a @plosbiology.org study that suggests a broadly applicable mechanism able to balance the maintenance of the steady-state with an effective stress response 🧪 #erythropoiesis Paper: plos.io/3KDskbX Primer: plos.io/4j4QBV1

Synergistic mechanisms of pleiotropic cytokines and lineage-specific factors. IL-17A dramatically enhances erythropoiesis, increasing the production of ProE precursors above levels generated by Epo alone. HSC, hematopoietic stem cell; MPP, multipotent progenitor; EBMP, erythroid/basophil-mast cell/megakaryocytic progenitor; BFU-E, erythroid burst-forming unit; CFU-E, erythroid colony-forming unit; ProE, pro-erythroblast; BasoE, basophilic erythroblast; PolyE, poly erythroblast; OrthoE, ortho-chromatic erythroblast; RBC, red blood cell. Created in BioRender. Wilson, N. (2025).

What underlies the dynamics of #RedBloodCell production? Nicola Wilson explores a @plosbiology.org study that suggests a broadly applicable mechanism able to balance the maintenance of the steady-state with an effective stress response 🧪 #erythropoiesis Paper: plos.io/3KDskbX Primer: plos.io/4j4QBV1

Synergistic mechanisms of pleiotropic cytokines and lineage-specific factors. IL-17A dramatically enhances erythropoiesis, increasing the production of ProE precursors above levels generated by Epo alone. HSC, hematopoietic stem cell; MPP, multipotent progenitor; EBMP, erythroid/basophil-mast cell/megakaryocytic progenitor; BFU-E, erythroid burst-forming unit; CFU-E, erythroid colony-forming unit; ProE, pro-erythroblast; BasoE, basophilic erythroblast; PolyE, poly erythroblast; OrthoE, ortho-chromatic erythroblast; RBC, red blood cell. Created in BioRender. Wilson, N. (2025).

What underlies the dynamics of #RedBloodCell production? Nicola Wilson explores a @plosbiology.org study that suggests a broadly applicable mechanism able to balance the maintenance of the steady-state with an effective stress response 🧪 #erythropoiesis Paper: plos.io/3KDskbX Primer: plos.io/4j4QBV1

Single-cell transcriptomics of the Epo/IL-17A synergism in erythropoiesis. Left: UMAP visualization of single-cell transcriptomes across conditions and tissues, colored by annotated cell states. MPP, multipotent progenitor; EBMP, erythroid-basophilic-megakaryocytic progenitor; BaMaP, basophil-mast cell progenitor; MegP, megakaryocyte progenitor; EosP, eosinophil progenitor; LyP, lymphoid progenitor; GMP, granulocyte monocyte progenitor; MoP, monocyte progenitor; imMo; immature monocyte; mMo, mature monocyte; NeuP, neutrophil progenitor; imNeu, immature neutrophil; mNeu, mature neutrophil; imB, immature B cell; proB, proB cell; T, T cell; cDC1/2, conventional dendritic cell 1/2; pDC, plasmacytoid dendritic cell; Mac, macrophage; EEP, early erythroid progenitor (BFU-e equivalent); CEP, committed erythroid progenitor (CFU-e equivalent); ProE, proerythroblast; BasoE, basophilic erythroblast; PolyE, polychromatic erythroblast; OrthoE, orthochromatic erythroblast; pyrenocytes, and reticulocytes. Right: Relative cell densities across the sampled RNA-Seq state space, evaluated in high dimensions and visualized on the UMAP plot. The plots are colored by the log2-transformed ratio of cell densities in the neighborhood of each sampled transcriptome, for each treatment pair as indicated.

#Erythropoietin can be an effective #anemia treatment, but not with cancer or chronic disease. This study identifies the pleiotropic #cytokine IL-17A as a stimulator of #erythropoiesis in vivo that acts by amplifying the response of erythroid progenitors to Epo @plosbiology.org 🧪 plos.io/3KDskbX

Single-cell transcriptomics of the Epo/IL-17A synergism in erythropoiesis. Left: UMAP visualization of single-cell transcriptomes across conditions and tissues, colored by annotated cell states. MPP, multipotent progenitor; EBMP, erythroid-basophilic-megakaryocytic progenitor; BaMaP, basophil-mast cell progenitor; MegP, megakaryocyte progenitor; EosP, eosinophil progenitor; LyP, lymphoid progenitor; GMP, granulocyte monocyte progenitor; MoP, monocyte progenitor; imMo; immature monocyte; mMo, mature monocyte; NeuP, neutrophil progenitor; imNeu, immature neutrophil; mNeu, mature neutrophil; imB, immature B cell; proB, proB cell; T, T cell; cDC1/2, conventional dendritic cell 1/2; pDC, plasmacytoid dendritic cell; Mac, macrophage; EEP, early erythroid progenitor (BFU-e equivalent); CEP, committed erythroid progenitor (CFU-e equivalent); ProE, proerythroblast; BasoE, basophilic erythroblast; PolyE, polychromatic erythroblast; OrthoE, orthochromatic erythroblast; pyrenocytes, and reticulocytes. Right: Relative cell densities across the sampled RNA-Seq state space, evaluated in high dimensions and visualized on the UMAP plot. The plots are colored by the log2-transformed ratio of cell densities in the neighborhood of each sampled transcriptome, for each treatment pair as indicated.

#Erythropoietin can be an effective #anemia treatment, but not with cancer or chronic disease. This study identifies the pleiotropic #cytokine IL-17A as a stimulator of #erythropoiesis in vivo that acts by amplifying the response of erythroid progenitors to Epo @plosbiology.org 🧪 plos.io/3KDskbX

Single-cell transcriptomics of the Epo/IL-17A synergism in erythropoiesis. Left: UMAP visualization of single-cell transcriptomes across conditions and tissues, colored by annotated cell states. MPP, multipotent progenitor; EBMP, erythroid-basophilic-megakaryocytic progenitor; BaMaP, basophil-mast cell progenitor; MegP, megakaryocyte progenitor; EosP, eosinophil progenitor; LyP, lymphoid progenitor; GMP, granulocyte monocyte progenitor; MoP, monocyte progenitor; imMo; immature monocyte; mMo, mature monocyte; NeuP, neutrophil progenitor; imNeu, immature neutrophil; mNeu, mature neutrophil; imB, immature B cell; proB, proB cell; T, T cell; cDC1/2, conventional dendritic cell 1/2; pDC, plasmacytoid dendritic cell; Mac, macrophage; EEP, early erythroid progenitor (BFU-e equivalent); CEP, committed erythroid progenitor (CFU-e equivalent); ProE, proerythroblast; BasoE, basophilic erythroblast; PolyE, polychromatic erythroblast; OrthoE, orthochromatic erythroblast; pyrenocytes, and reticulocytes. Right: Relative cell densities across the sampled RNA-Seq state space, evaluated in high dimensions and visualized on the UMAP plot. The plots are colored by the log2-transformed ratio of cell densities in the neighborhood of each sampled transcriptome, for each treatment pair as indicated.

#Erythropoietin can be an effective #anemia treatment, but not with cancer or chronic disease. This study identifies the pleiotropic #cytokine IL-17A as a stimulator of #erythropoiesis in vivo that acts by amplifying the response of erythroid progenitors to Epo @plosbiology.org 🧪 plos.io/3KDskbX

Starting with a great #erythropoiesis session at the Red Cell Club Meeting #RCC #RedCell

Examining mechanisms relevant for restoring #Erythropoiesis & mitigation of pro-inflammatory IFNγ action in #MouseModel #Anemia of #Inflammation (AI) doi.org/10.1182/bloo... #TranslationalScience

Anti-inflammatory signals promote the transition to differentiation of SEPs. buff.ly/2b2lvLf #hemesky #erythropoiesis

Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to Salmonella Typhimurium Infection in Aryl Hydrocarbon Receptor–Deficient Mice Aryl hydrocarbon receptor deficiency in mice results in increased susceptibility to chronic systemic Salmonella infection due to enhanced erythropoietin-dr

Dysregulation of #Stress #Erythropoiesis and Enhanced Susceptibility to #Salmonella #Typhimurium #Infection in #Aryl #Hydrocarbon #Receptor-Deficient Mice; #JInfectDis #FoersterLab @unibonn.bsky.social shorturl.at/tSUdF

Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos The transition of an embryo from gastrulation to organogenesis requires precisely coordinated changes in gene expression, but the underlying mechanisms remain unclear. The RNA-binding protein Trim71 i...

Impaired primitive #erythropoiesis and defective #vascular #development in #Trim71-KO #embryos #LifeSciAlliance #KolanusLab @unibonn.bsky.social #organogenesis #gene-expression shorturl.at/Vnhu6

Lower serum #magnesium level is an important risk factor for #erythropoiesis -stimulating agents hypo-responsiveness in hemodialysis patients

Lower serum magnesemia is an important risk factor for ESAs hypo-responsiveness with more dialysis-associated symptoms.
ejim.springeropen.com/articles/10....

Cluster funded publication in @NatureComms with @kuzina_mariia and @levkinlab on the inhibition of #lysyl oxidases synergizes with 5-azacytidine to restore #erythropoiesis in myelodysplastic and myeloid #malignancies: https://doi.org/10.1038/s41467-023-37175-8 #cancer #therapies