#WeekendRead! #InterferonFriendOrFoe? @jeffdowney11.bsky.social @filswirski.bsky.social &co show @cp-immunity.bsky.social that upon severe flu lung infection, IAV is transported to the heart by DCs, where it infects cardiomyocytes to drive IFN-I, causing cardiac dysfunction! doi.org/10.1016/j.im...

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis Although the immune system is a significant barrier to tumor growth and spread, established tumors evade immune attack and frequently colonize immune …

#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!

Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection | Journal of Experimental Medicine | Rockefeller University Press Broomfield et al. demonstrate that early type I interferon blockade alters CXCR3 chemokine regulation and cell location to promote an antigen-dependent CD8

#WeekendRead! #InterferonFriendOrFoe!
@benjbroom.bsky.social @groomlab.bsky.social &co show @jem.org that transient type I IFN inhibition upon LCMV infection or a mRNA vaccine boosts stem-like memory CD8 T cells by altering their location within the draining lymph node, potentiating virus protection

#interferonFriendorFoe ? So happy to have hosted my friend @boulantlab.bsky.social today at @ciml.bsky.social , showing nice new data on how basal #IFN lambda is essential for tight junction formation in epithelial cells! Very nice work from him and @meganstanifer.bsky.social

#WeekendRead! #InterferonFriendOrFoe?! Ding, Hou &co show @co-cellhostmicrobe.bsky.social that rota & reovirus induce diarrhea (in neonate mice) via MAVS-IFN lambda downregulating a ion exchanger! IFNL is increased in human IBD biopsies as we also recently showed👉 doi.org/10.1016/j.cell.2024.10.010

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.

#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!