#ipRGCs

ipRGC properties prevent light from shifting the SCN clock during daytime Nature - The inability of intrinsically photosensitive retinal ganglion cells to shift the circadian clock in the suprachiasmatic nucleus during daytime is caused by light-dependent depolarization...

Why doesn’t #light reset our #circadian clock during the day? The gate isn’t only in the brain (SCN), but also in the eye. The #ipRGCs limit their own firing, which shapes when light can produce a phase shift.
rdcu.be/eZ8cH

The Guardian interview with Professor Russell Foster CBE

"His biggest scientific achievement is the discovery that light-sensitive cells in the retina unrelated to vision synchronise us to day and night. If these are lost or damaged things can get seriously out of whack..." #ipRGCs
www.torch.ox.ac.uk/article/the-...

Non-image-forming photoreceptors improve visual orientation selectivity and image perception Using two-photon and multi-channel recordings from mouse primary visual cortex V1, Shi, Zhang, et al. demonstrate that intrinsically photosensitive retinal ganglion cells improve V1 orientation selectivity by differentially modulating excitatory and inhibitory neurons. This modulation by ipRGCs ultimately improves orientation discrimination in both mice and humans.

And another role for #ipRGCs, the photoreceptors mainly responsible for non-visual responses to #light such as circadian clock resetting and regulation of alertness and mood, enhancing orientation selectivity in mouse visual cortex.
www.cell.com/neuron/fullt...

Light modulates oscillatory alpha activity in the occipit... The discovery of intrinsically photosensitive retinal gan...

Light modulates oscillatory alpha activity in the occipital cortex of totally visually blind individuals with intact non-image-forming photoreception https://www.nature.com/articles/s41598-018-35400-9 #ipRGCs #desynchronization