Accessing a wealth of structure data to integrate with your #MSA is possible accessing the #3DBeacons network through #Jalview.
Get experimentally determined structures from @pdbeurope.bsky.social as well as predicted structure models from #AlphaFoldDB, @swiss-model.bsky.social and other providers!
#Jalview goes the extra mile! Remember the integration with @chimerax.ucsf.edu or #PyMOL? Well, you can use these viewers to inspect #AlphaFold confidence scores #pLDDT and #PAE in multiple #sequence alignment and #structure!
Multiple structure prediction confidence analysis made easy with Jalview!
I didn't know that... Or did I? You can pretty much do anything in sequence and structure analysis with Jalview!
ANYONE: "Hmmm, I wonder if I could cluster a group of sequences by features such as predicted ligand sites and then analyse amino acid conservation within each group..." 🤔
#JALVIEW: YES
I cannot believe the license fee #GeneCodes want to charge users for #Sequencher when there are many free alternatives out there, like #UGENE, #MEGA, #Jalview etc.
What are you using for things like local sequence alignment, primer design, ORF finder?
#bioinformmatics #genomics