Day 8 of #Lamotrigine. I’m told it can take up to 6 weeks to work. I’m holding on.
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Hashtag
#lamotrigine
Advertisement · 728 × 90
Significant Link Found Between HLA-A3201 and Risk of Lamotrigine-Induced DRESS Reactions #USA #Milwaukee #DRESS #HLA-A3201 #Lamotrigine
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I had the most vivid dreams last night. Turns out I should thank #Lamotrigine for that!
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Anyone else on a similar mix of medication with success? Looking for positivity, ideally.
Diagnosis:
Treatment Resistant Depression
Anxiety Disorder
OCD
cPTSD
Anorexia
Also Autistic
#Lamotrigine #Topiramate #Aripiprazole #Vortioxetine
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My GP has issued a prescription for Lamotrigine that I need to go collect at some point. Wish me luck. #Lamotrigine
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💊 Real-world data backs #lamotrigine for non-dystrophic myotonias
📉 Myotonia Behavior Score dropped from 3.3 → 1.8 over ~26 months
🧬 Benefits seen in CLCN1 & SCN4A variants
✅ No severe or cardiac AEs
Read more: www.neurologylive.com/view/real-wo...
#Neurology #RareDisease #MedTwitter #Myotonia
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Mood Stabilizers: Lithium, Valproic Acid, Carbamazepine & Lamotrigine #MoodStabilizers #iPrkashMishra #Lamotrigine #BipolarDisorder #Psychiatry
Mood Stabilizers: Lithium, Valproic Acid, Carbamazepine & Lamotrigine
#MoodStabilizers #iPrkashMishra #Lamotrigine #BipolarDisorder #Psychiatry
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⁉️Quel #antiépileptique puis-je prendre pendant ma grossesse? Une question récurrente qui nous est posée....🚨Tous les #antiépileptiques sont tératogènes c'est à dire foeto-toxique. Cependant le #Lamictal = #Lamotrigine semble être le moins foeto-toxique.
#prescrire dec 2025
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Day 7: Not known as harmful in pregnancy but dose kept as low as possible with careful monitoring of serum concn. In view of anti-folate action of #lamotrigine, SPC recommends taking folic acid while trying to conceive/in early pregnancy. Drug is passed on in lactation & can > ADEs in the infant
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Day 6 (cont) #lamotrigine can decrease efficacy of combined hormone contraception & vice versa. If no alternative contraception possible, dosing alterations are needed with additional monitoring of lamotrigine levels
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Day 6: Multiple DDIs but few ‘severe’. These include a reduced effect of drosperidone & enzyme inhibitors e.g ritonavir which lower lamotrigine levels. Enzyme inducers e.g valproate increase levels of #lamotrigine (NOT exhaustive)
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Day 5 (cont). #lamotrigine is on the category 2 list for ‘risk’ linked to brand switching advising clinical judgment when deciding if a switch is safe
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Day 4: #lamotrigine blocks voltage gated Na channels. Stabilising the membrane inhibits release of glutamate (excitatory) which is involved in generating convulsion. May have some antagonism of Ca channels, which modulates GABA. Precise dynamic unknown & even less understood in bipolar disorder
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Day 3 (cont) NOTE polymorphisms can cause UGT functional differences which can impact #lamotrigine drug concentration in either direction
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Day 3: #lamotrigine has good oral absorption with high bioavailability. Liver metabolism by UGT enzymes. Dose reduction needed in severe renal or hepatic impairment + for moderate hepatic impairment. Urinary excretion. T½~24-35 hrs, but ↑variation if combined with enzyme inducers/inhibitors.
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Day 2 (cont) #lamotrigine is also used as a mood stabiliser for adults with or without valproate. After up-titration, maintenance dose is 100-200mg/day in 1-2 divided doses; maximum 400mg/day
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Day 2: #lamotrigine is an oral agent licensed for mono/adjunctive therapy for a range of partial & general seizure types in >12 yrs. Licensed as adjunct for some child seizures > 2 yrs. Dose is age & weight dependant & slowly titrated at set intervals.
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Day 1: The search for safer & broader acting anti-epileptics led to investigation of folate antagonists (believed to be pro-convulsive) in the 1980s. #lamotrigine has only mild anti-folate properties, but was licensed early 1990s as an effective anti-epileptic drug & later for bipolar disorder
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7 days of #lamotrigine starting today
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A single dose of lamotrigine causes subtle changes in emotional memory #Science #HealthandMedicine #MentalHealth #Lamotrigine #EmotionalMemory #MentalHealthResearch
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Pharmacodynamic interactions between seletracetam and antiseizure comedications in the human photosensitivity model
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #lamotrigine #levetiracetam #photoparoxysmalresponse #photosensitiveepilepsy #synapticvesicleglycoprotein2A #valproate
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Letter to editor
Cutaneous adverse drug reactions induced by anticonvulsants: Proposal for allergological work-up and contraindications
#Anticonvulsants #Lamotrigine #Carbamazepine #DrugReaction #AllergologicalWorkUp #CrossReactivity
www.em-consulte.com/article/1732...
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This #RCT does not find improvement in cognitive functioning after short-term treatment with #lamotrigine in adolescents with #neurofibromatosis type 1 #NF1
buff.ly/bfPU0UI
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Key point: Clinically relevant concentrations of lamotrigine block predominant cardiac sodium channel isoform NaV1.5.
doi.org/10.1111/epi....
#epilepsy #ILAE #flecainide #lamotrigine #reentry #ventriculartachycardia
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Congratulations to collaborator extraordinaire Prez Radwanski on the first publication of 2025: doi.org/10.1111/epi....
Delighted to have made some contributions to this work, where we uncover mechanisms underlying deadly proarrhythmic impacts of the #epilepsy #drug #lamotrigine.
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Lamotrigine dreams, almost nightmares, does this calm down? #epilepsy #lamotrigine
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