Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and In Vivo in Mice Acyl glucuronides are common metabolites of carboxylic acids. They can be reactive and cause adverse events. The acyl glucuronide metabolite of delta-9-tetrahydrocannabinol (THC) is abundant in humans after THC consumption but acyl glucuronide formation from the cannabidiol (CBD) metabolite 7-carboxy-cannabidiol (7-COOH-CBD) has not been previously described. Here, we identified and characterized both acyl and phenolic glucuronides of 7-COOH-CBD formed in human liver, kidney, and intestinal microsomes. The 7-COOH-CBD-acyl-glucuronide was mostly formed by UGT1A1 and UGT1A3, while the 7-COOH-CBD-phenolic-glucuronide was formed by UGT1A9. 7-COOH-CBD-acyl-glucuronide formation was also detected in vivo in mice. 7-COOH-CBD-acyl-glucuronide showed extensive acyl migration while 11-COOH-THC-glucuronide did not. Human serum albumin enhanced migration, while liver fatty acid binding protein (FABP1) protected against 7-COOH-CBD-acyl-glucuronide migration. When corrected for unbound fraction, FABP1 increased 7-COOH-CBD glucuronidation efficiency. These findings suggest that 7-COOH-CBD-acyl-glucuronide is a metabolite of CBD in humans and may play a role in CBD related liver toxicity.

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and In Vivo in Mice pubs.acs.org/doi/10.1021/... @acs.org

#KellyChibale #DrugMetabolism #LiverToxicity #Pharmacokinetics #MedicinalChemistry #DrugSafety

Hepatoprotective and PXR-modulating effects of Erodium guttatum extract in propiconazole-induced toxicity

Erodium guttatum hydroalcoholic extract protects against PCZ-induced #LiverToxicity through #antioxidant-rich #phenolics that restore liver health and favorably interact with PXR, supporting its potential as a natural #hepatoprotective agent.
Open Chemistry: doi.org/10.1515/chem...

Intellia shares fall after hospitalised CRISPR patient dies Shares in gene-editing specialist Intellia Therapeutics came under renewed pressure today after a patient in one of its clinical trials died.

#Shares in gene-editing specialist #IntelliaTherapeutics came under renewed pressure today after a patient in one of its clinical trials who was hospitalised for #livertoxicity died.

pharmaphorum.com/news/intelli...

After an epic Macro Party 🥳, we’re back for Day 3 at #MPSSummit!
Come see our posters on #LiverToxicity, #Immune-on-chip, the #OrganDisc, & our brand-new #MOS Core Facility! 🚀

Poster Session 3 | 10–11:30 AM | Board #394
Poster Session 4 | 4:30–6 PM | Boards #229, #423, #439

Grab a ☕️ and stop by! 🙌

The Potential Consequences of Taking Excessive Amounts of Steroids, Such as Testosterone Enanthate Discover the potential risks of excessive testosterone enanthate use, including cardiovascular damage, liver toxicity, hormonal imbalances, and mental health issues.

The Potential Consequences of Taking Excessive Amounts of Steroids, Such as Testosterone Enanthate

strongmaster.net/the-potentia...

#testosteroneenanthate #steroidabuse #anabolicsteroids #musclegrowth #healthrisks #cardiovasculardamage #livertoxicity #mentalhealth #roidrage #infertility

Transcriptomics and in vitro tests reveal clothianidin’s genotoxic potential, but a weight-of-evidence decision suggests it’s unlikely to pose risks to humans:
doi.org/10.1016/j.fc...
#science #health #toxics #livertoxicity #HBM4EU