Sorry it's so late, @spectralanomally.bsky.social!

To celebrate my cuz's new model, I commissioned this from @karaarts.bsky.social!

Med students are the future of healthcare, & I look forward to your bright future as an MD! Can't wait to work together some day!!

#SpectralSketches #medsky

Using the linear references from the pangenome to discover missing autism variants | Nature Communications To better understand large-effect pathogenic variation associated with autism, we generated long-read sequencing (LRS) data to construct phased and near-complete genome assemblies (average contig N50 = 43 Mbp, QV = 56) for 189 individuals from 51 families with unsolved cases. We applied read- and assembly-based strategies to facilitate comprehensive characterization of de novo mutations, structural variants (SVs), and DNA methylation. Using LRS pangenome controls, we efficiently filtered >97% of common SVs exclusive to 87 offspring. We find no evidence of increased autosomal SV burden for probands when compared to unaffected siblings yet observe a suggestive trend toward an increased SV burden on the X chromosome among affected females. We establish a workflow to prioritize potential pathogenic variants by integrating autism risk genes and putative noncoding regulatory elements defined from ATAC-seq and CUT&Tag data from the developing cortex. In total, we identified three

Discover missing autism variants: Analyzed 189 individuals from 51 families using long-read sequencing to find de novo mutations, SVs, and methylation! PMID:41577710, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-68378-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GLP-1 receptor agonists slash cardiovascular risks and slow renal decline in high-risk type 2 diabetes patients while promoting weight loss.

by Rosen CJ and Ingelfinger JR in N Engl J Med #MedSky

👉 get more here

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMra2500106

Common sense oncology values to action: a patient led framework for randomized clinical trial design AbstractBackground. Randomized controlled trials (RCTs) are the foundation of oncology drug development, yet increasing concern exists that some prioritize

...9 core values w/associated actions: meaningful question & benefit, patient partnerships, #informedconsent, generalizability, optimal comparator arm, minimal participant burden, timely results feedback, clear dissemination academic.oup.com/jnci/advance... #MedSky #PatientEngagement #CanSky #OncSky

Discover Electronics

A study published in Discover Electronics presents a comprehensive literature survey of different blood glucose level monitoring techniques available, distinguishing invasive and non-invasive ones.
bit.ly/3ZDOhvC

#MedSky #STS

#EHJCVI 🔍 New insights into PFO risk. Totaro et al. identify “funnel-type” PFO morphology on 3D-TEE as a novel high-risk feature 🧠📊 Read more 👉 doi.org/10.1093/ehjc... #MedSky

#OutOfHospitalCardiacArrest outcomes

doi.org/10.1111/1742...

@wileyhealth.bsky.social
#MedSky #EMSky #EMedSky #emimcc #ACEM

#AcuteStrokePathway use in Tasmanian EDs
doi.org/10.1111/1742...

#OpenAccess

@drvtran.bsky.social
@wileyhealth.bsky.social
#MedSky #EMSky #EMedSky #emimcc #ACEM

Infrared vs. Traditional Sauna: Which Is Actually Better for You? A thermoregulation physiologist, cardiologist, and dermatologist settle the debate over a hot topic.

Infrared vs. Traditional Sauna: Which Is Actually Better for You?

www.gq.com/story/infrar...

#Lifestyle #Health #Wellness #Medical #Medsky #Sauna #Infrared #InfraredSauna #Heat #Sweat #Skin #SkinHealth #Derm #DermSky #Heart #HeartHealth #Cardio #Shopping

Packed red blood cell administration within the LifeFlight Medical Services retrieval network

doi.org/10.1111/1742...

@wileyhealth.bsky.social
#MedSky #EMSky #EMedSky #emimcc #ACEM

💥🆕 Inhaled Antibiotics for Ventilator-Associated Pneumonia: Is It Ready for Prime Time?
Our new article is out
👇
bit.ly/48GgLt7
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social

https://doi.org/10.1001/jamaneurol.2026.0548 No description available

Exciting insights! 6 cases of interstitial lung disease noted in patients after long-term ocrelizumab treatment for multiple sclerosis. 🤔 PMID:41941213, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.0548 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CRISPR Gene Editing Normalizes Hemoglobin in Sickle Cell Patients; 27 of 28 Remain Vaso-Occlusive Event-Free Post-Treatment.

by Hanna R, Frangoul H (...) Walters MC et 13 al. in N Engl J Med #MedSky

👉 get more here

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2415550

Scientists invented a fake disease. AI told people it was real Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?

Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. A feature in Nature explores why AI chatbots were telling people the condition was real. #medsky 🧪

A cancer patient enrolled in this trial died because of duloxetine. Adding insult to injury it was already known that duloxetine doesn't work (and why should it?) in the prevention or treatment of chemotherapy induced neuropathy spcare.bmj.com/content/13/1... #MedSky #Oncosky #Pharmsky

Protected PCI and Cardiogenic Shock Interventional Octagon 4/14 @ 9 pm ET - Cardiovascular Innovations Please join us at the CVI’s Interventional Octagon competitive case-based learning webinar on 4/14/26 at 9 pm ET. This CME session will focus on Protected PCI and Cardiogenic Shock.  Fellows...

Join us for a Coronary Interventional Octagon - Protected PCI and Cardiogenic Shock. April 14, 9 pm ET. Complimentary registration are at: cvinnovations.org/2026/03/05/c... #cardiology #cme #webinar #medsky #cardiosky

Who profits from RFK Jr.'s decisions?
🧪 #medsky #health

Why join #WednesdayWalkoutsforHealth?

Reason 2: Solidarity is great for the soul.

#MedSky #Resist

Why do dog eyes age so differently than human eyes? It’s not fair that their eyes start to go cloudy in their teen years but humans generally have many decades before that. Any vet eye specialists who have info? #vetsky #medsky #scisky

#MedSky

No new measles cases reported in Florida over the past week The latest case count suggests the outbreak may be slowing, but it does not indicate that transmission has been eliminated.

Florida has the fourth-highest measles case count in the US.

#Medsky #IDsky #epidemiology #pediatrics #MMR #vaccines #publichealth

Cannabinoid CB1 receptors drive oligodendrocyte maturation during myelin regeneration

#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane‐Exposed Neonatal Mice Sevoflurane, a widely used anaesthetic, impairs cognitive and fine motor functions in neonatal mice. Resveratrol of 30 mg/kg was administered intraperitoneally 1 h before each exposure. Myelinati

Sevoflurane, a widely used anaesthetic, impairs cognitive and fine motor functions in neonatal mice. Resveratrol of 30 mg/kg was administered intraperitoneally 1 h before each exposure. Myelination and neuroinflammatory response...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

🥜⭐️ #Peanuts UNsalted ⭐️🥜
#medsky
myhealthopedia.com/peanuts-nutr...
🥜 Complete guide to these awesome nuts!

Muscone promotes remyelination and alleviates Parkinson’s disease by targeting FKBP5 in MPTP-induced mouse model There is a need for new treatments for Parkinson''s disease (PD). Promoting myelin renewal might be one promising avenue. The study aimed to evaluate the therapeutic efficacy of the natural co

There is a need for new treatments for Parkinson''s disease (PD). Promoting myelin renewal might be one promising avenue. The study aimed to evaluate the therapeutic efficacy of the natural compound muscone (Mus) on PD pathology ...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention: 10-year follow-up of the HOST-EXAM trial During 10 years of follow-up, clopidogrel monotherapy, compared with aspirin monotherapy, was associated with lower rates of the primary composite, ischaemic, and bleeding outcomes, but not all-cause mortality after PCI. These findings support consideration of clopidogrel as an alternative to aspirin for long-term antiplatelet monotherapy during the chronic maintenance phase after PCI.

"Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention: 10-year follow-up of the HOST-EXAM trial."
Publié ce jour dans @thelancet.com.
#MedSky #CardioSky
www.thelancet.com/journals/lan...

Guidelines for older patients in the ED with possible delirium. #MedSky
thesgem.com/2026/04/sgem... @casinoshiftmd.bsky.social @acepnation.bsky.social

NIM5 series brain-penetrant NLRP3 inflammasome inhibitors suppress neuroinflammation in EAE and Alzheimer''s models Brain-penetrant NLRP3 inhibitor is needed for CNS-targeted therapeutic development. In vitro, systemic administration attenuated neuronal injury and improved behavioral outcomes in both EAE and Aβ-ind

Brain-penetrant NLRP3 inhibitor is needed for CNS-targeted therapeutic development. In vitro, systemic administration attenuated neuronal injury and improved behavioral outcomes in both EAE and Aβ-induced mouse models.
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Because the point is to destroy the engine that powers America - Science, Technology, Mathematics, & Engineering.

Exactly what Putin wants.

#MedSky #GreenSky 🧪
@standupforscience.net

Top Infectious Disease News Stories Week of April 5 - April 11 | Contagion Live This week, read about genomic surveillance of Candida auris, commentary on vector-borne disease diagnostics, the latest measles numbers, and more.

This week, read about genomic surveillance of Candida auris, commentary on vector-borne disease diagnostics, the latest measles numbers, and more. #IDsky #Medsky

www.contagionlive.com/view/top-inf...