Genome-scale metabolic modelling of trimethoprim’s mode of action reveals free ATP salvaged to restore purine pool Trimethoprim is a clinically important antibiotic for treating urinary tract infections yet its mechanism of killing remains elusive due to a cascade of effected metabolic reactions. Metabolites avail...

Once you have read that gem why not treat yourself to another from Cailean's PhD with @gemma-langridge.bsky.social

This preprint uses genome-scale #metabolicmodelling to see how #trimethoprim effects 𝘌. 𝘤𝘰𝘭𝘪's metabolism & how these can be selectively counteracted with growth media supplementation