This study focused on using adjuvant compounds & a genome-wide screen with #trimethoprim - #chloramphenicol to identify gene knockouts in E. coli that confer hypersensitivity to one or both antibiotics. Trimethoprim, an anti-folate, is used for broad-spectrum treatment & prophylaxis,

Genome-scale metabolic modelling of trimethoprim’s mode of action reveals free ATP salvaged to restore purine pool Trimethoprim is a clinically important antibiotic for treating urinary tract infections yet its mechanism of killing remains elusive due to a cascade of effected metabolic reactions. Metabolites avail...

Once you have read that gem why not treat yourself to another from Cailean's PhD with @gemma-langridge.bsky.social

This preprint uses genome-scale #metabolicmodelling to see how #trimethoprim effects 𝘌. 𝘤𝘰𝘭𝘪's metabolism & how these can be selectively counteracted with growth media supplementation

Melioidosis and glanders - Symptoms, diagnosis and treatment | BMJ Best Practice Melioidosis and glanders are both caused by bacteria of the genus. Melioidosis is characterised by fever, pneumonia, and abscesses, although there is a spectrum of severity from mild, localised infe...

#Medsky🧪 #IDsky #microsky #pharmasky #publichealth The study highlights the high frequency of adverse drug reactions (ADRs) associated with #trimethoprim / sulfamethoxazole (TMP/SMX) during the eradication phase of #melioidosis therapy bestpractice.bmj.com/topics/en-gb... @bmj.com

Amneal Pharmaceutical LLC Issues a Nationwide Recall of Sulfamethoxazole / Trimethoprim Tablets, USP, 400 mg/80 mg Only, Due to Microbial Contamination Amneal Pharmaceutical LLC, is recalling three lots of Sulfamethoxazole/Trimethoprim Tablets, USP, 400 mg/80 mg to the consumer level as the tablets may exhibit black spots on the tablet surface due to...

#Medsky🧪 #pharmasky #publichealth @fda.gov #Sulfamethoxazole / #Trimethoprim Tablets USP, 400 mg/80 mg Only by Amneal Pharmaceutical: Recall - Due to Microbial Contamination . The product is for the treatment of Urinary tract infections caused by susceptible strains of the following organisms: