Stochastic misfolding drives the emergence of distinct α-synuclein strains Structural variation among α-synuclein aggregates underlies distinct synucleinopathies, yet how this variability arises remains unknown. In this article, So et al. demonstrate that α-synuclein randoml...

Stochastic #misfolding drives the #emergence of distinct #α-synuclein strains: Neuron www.cell.com/neuron/fullt...

Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations

This review provides a comprehensive analysis of #ProteinFolding biology, highlighting #MolecularChaperones, causes of #misfolding, disease links, and therapeutic strategies targeting #proteostasis to restore protein homeostasis. #medsky

#OpenAccess #STTT: doi.org/10.1038/s413...

Protein accidentally lassos itself, helping to explain unusual refolding behavior Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded proteins t...

Protein accidentally lassos itself, helping to explain unusual refolding behavior phys.org/news/2025-03... #Protein #misfolding #PGK #StretchedExponentialRefoldingKinetics #NoncovalentLassoEntanglement #Lasso #entanglement

Brainwide silencing of #prion protein by AAV-mediated delivery of an engineered compact epigenetic editor

1) Prion disease is caused by #misfolding of the #prion #protein ( #PrP )into pathogenic self-propagating conformations, leading to rapid-onset dementia and death.

Research Article: Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis -Protein Science

#proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes

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