La déformante maladie (épisode 344) Au début du 20ème siècle, la rencontre d’une patiente et d’un médecin a permis de mettre en lumière les premiers éléments qui allaient bouleverser ce qui était imaginé autour des maladies. Bertha Elschker est née le 8 décembre 1890 dans le petit village de Jeżów Sudecki dans l’actuelle Pologne. Elle est la dernière-née d’une fratrie … Continuer la lecture de La déformante maladie (épisode 344) →

Et les références scientifiques : cervenargo.hypothese...

#neurosciences #vulgarisation #cerveau #science #étudedecas #CreutzfeldtJakob #encéphalopathie #spongiose #histoire #prion

Merci pour vos écoutes et partages ☺️

#podcasthon @institutducerveau.bsky.social

#neurosciences #vulgarisation #cerveau #science #étudedecas #CreutzfeldtJakob #encéphalopathie #spongiose #histoire #prion

Merci pour vos commentaires, partages et abonnements !

#podcasthon @institutducerveau.bsky.social

#neurosciences #vulgarisation #cerveau #science #étudedecas #CreutzfeldtJakob #encéphalopathie #spongiose #histoire #prion

Merci pour vos écoutes et partages ☺️

#podcasthon @institutducerveau.bsky.social

#neurosciences #vulgarisation #cerveau #science #étudedecas #CreutzfeldtJakob #encéphalopathie #spongiose #histoire #prion

Merci pour vos partages 😉

#podcasthon @institutducerveau.bsky.social

#Valleys are #boring
but #mountainous #regions are
just #hill #areas.

#vss365 #haiku
#memes #pun #puns #punny

#prion #prions #covAIDS #graphene #genocide #COINTELPRO #denial #ClimateGate #PsyOp #PsyOps #InfoWars #counterintelligence #Epstein #Mossad #CIA #MI6 #CoverUp #Majestic12 #QAnon #NSA #NASA

I said the other day, and I will say it again: what if the cannibals all have #prion disease from eating human flesh? Prion disease often presents as dementia and addled gait 🤔

Both painful and immensely satisfying to read about the "misfolded" proteins (or disordered on es easily loosing shape) - in the context of Alzheimer, Parkinson and particularly include Multiple System Atrophy (MSA) which strikes very close to me. This misfolding is close to the #prion diseases.

Interesting! Inhibition of oligosaccharyltransferase complex results in a 50% reduction in cell surface expression of the prion protein PrP(c). Such molecules cannot convert into multiple strains of PrP(Sc). OST as a novel therapeutic target in proion diseases?
tinyurl.com/2s4a29zr
#glycotime
#prion

A wolf in synuclein clothing: Creutzfeldt-Jakob disease disguised as MSA Rapidly progressing neurological disease should immediately signal a possible prion disorder. Learn key diagnostic clues to distinguish Creutzfeldt-Jakob disease from mimics like multiple system…

#MedCase - Rapidly progressing neurological disease should immediately signal a possible #prion disorder.

Learn key diagnostic clues to distinguish Creutzfeldt-Jakob disease from mimics like multiple system atrophy.

👉 buff.ly/FIsDTyz

#NeuroSky #CJD

Hilarious.

1. #Prion an RNA & DNA predecessor can be seen to self-construct.

1a. This only has to happen once for all life capable planets as asteroid hits splash prion, cell or animal into space that can survive until splashdown.

2. DNA easier to maintain on prior Earth ecosystems eg Snowball.

Deli dana nedir, ne yapmalı? - OLAY NET Ankara’da yoğun bakımda izlenen bir hastada “deli dana” hastalığı (vCJD) ön tanısı konulmasının ardından, Bolu’da bir

Deli dana nedir, ne yapmalı? olaynet.net/2025/11/deli... #Ankara Bolu vakası #hayvandan bulaş #prion hastalığı #sinir sistemi bozulması #tedavisiz ilerleyiş #Gündem

Florida wildlife officials discover second case of ‘zombie deer disease’ in state Experts are enforcing emergency measures to prevent the spread of the highly contagious neurodegenerative disease

Officials in #Florida discover second case of ‘zombie deer disease’ in state ...

| #ChronicWastingDisease | #CWD | #prion | #deer | #wildlife | By @richlusc.bsky.social via @theguardian.com

10/24/2024-B

Wanted to do a bit more than the standard Zombie, so here is this rot pile
#scp #scpfoundation #scp008 #zombie #prion #necrosis #exposedbones #corpse #livingdead

Original post on dmv.community

[Medical Death Discussion]

#Science #Prion #Death
Scientifically Interesting Ways To Die

Family forgets how to sleep

The really wild part of this, is the Prion that causes this mutation, is STILL ALIVE in the brain donated to science, decades after the man died […]

#bskyart #artai #protein #activesite #polypeptide #conformation #prion #iconoplasm #AIArt #AIArtist #AIArtwork #AIimages #GenArt #DigitalArt #AIArtGallery #AIGeneratedArt #AIArtCommunity #synthart #weirdcore

Stare Harder. Stare Longer.

Logo

‘’The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information from DNA to protein via RNA. #biology #Centraldogma #DNA #molecularbiology #prion #PROTEIN #Rajeevsoni #Reviews #RNA
www.scientificeuropean.co.uk/sciences/bio...

#prion #proteins

prion-like proteins in the worm gut can form amyloid fibrils and are linked to memory impairment and oxidative stress #Amyloid #Prion #Neurodegeneration #Microbiome #Gut #UABBarcelona ➡️ www.embopress.org/doi/full/10....

🧠 Don't miss the next HT External Seminar Series event! On 4 July, join us in Milan for a talk by Adriano Aguzzi on Functional #Genomics of the #Prion Life Cycle.

Register by 3 July 👉 humantechnopole.it/en/training/...

The First Synthetic 'Mini Prion' Could Help Study Diseases Like Alzheimer's Alzheimer's disease and other neurodegenerative conditions can sometimes feature damaging clumps of tau proteins that have become deformed.

The First Synthetic 'Mini Prion' Could Help Study Diseases Like Alzheimer's Scientists have successfully created the first synthetic "mini prion," a groundbreaking advancement that could enhance research into neurodegenerative... @cosmicmeta.io #Prion

https://u2m.io/zdsard9N

From SARS_Cov2 (COVID 19) on 🦣:

Just in from my #CDC sources:

10+% of #Wisconsin’s deer are now infected w/Chronic Wasting Disease a fatal, incurable #prion disease.

It’s spreading fast.

#RFKjr calls for silence.

A deliberate effort to suppress critical #PublicHealth information.
1

530: Robert Klitzman | Person Place Thing with Randy Cohen Person Place Thing with Randy Cohen is an interview show based on this idea: people are particularly engaging when they speak not directly about themselves but about something they care about. Guests ...

Catch my conversation with @randycohen48.bsky.social for Person Place Thing here: personplacething.org/530-robert-k...

#healthcare #spirituality #religion #chaplains #newguinea #prion #kuru #Creutzfeldt-jakobdisease #cjd #neuro #stoneage #bioethics

During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

2 in Oregon die of rare brain disease Health officials are still investigating the cause, but most cases are never definitively solved.

Two #Oregon deaths due to rare #brain #disease ...

| #CreutzfeldtJakob | #prion | #protein | #dementia | Via oregonlive .com

During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

RT-QuIC Reactivity in the Brain and Other Organs and Tissues in Early, Middle-early, Middle-late and Terminal Stages of Scrapie Agent 263K Intracerebral Infection in Hamsters This study analyzed prion seed distribution in the CNS and peripheral tissues of hamsters using RT-QuIC at various stages of scrapie agent 263K infection.

This study analyzed prion seed distribution in the CNS and peripheral tissues of hamsters using RT-QuIC at various stages of #scrapieagent263K infection.

Read More: tinyurl.com/3axbbcwv

#prion #hamster #RTQuIC #SD50 #Zoonoses #zoonosis #Zoonotics #Zoonoticdiseases @scienceopen.bsky.social

New test distinguishes between #prion disease and other causes of rapidly progressive #dementia - Insights news.mayocliniclabs.com/2025/02/03/n...
#Aging #Medicine #dementia #LabTesting

‘Don’t call it zombie deer disease’: scientists warn of ‘global crisis’ as infections spread across the US The contagious, fatal illness in deer, elk and moose must be taken seriously, say experts as it takes hold in the US and reaches other countries. While it has not infected humans yet, the risk is grow...

The contagious, fatal illness in deer, elk and moose must be taken seriously, say experts as it takes hold in the US and reaches other countries. While it has not infected humans yet, the risk is growing
#ChronicWastingDisease #CWD #InfectiousDisease #Prion