#TRPC6 channels are implicated in pathogenesis of severe #nephrotic syndromes. This study of TRPC6 in normal physiological #podocyte functions reports roles in #MMP7-shedding of #nephrin ectodomains and #apoptosis.
doi.org/10.14814/phy...
#Renal #IonChannels
Hashtag
#nephrin
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They applied these principles to samples affected by #autoimmune conditions. Not only could they see a difference between the samples, but quantifying the distribution of #Nephrin showed a significant difference, making this method suitable for studying #DiseaseMechanisms and maybe for #Diagnostics.
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Roses are red 🌹
Violets are blue
Minimal Change Disease
Has autoantibodies too.
This #ValentinesDay give your podocytes some ♥️ by listening to our upcoming @NephJC_Podcast episode on #nephrin autoantibodies in MCD, taping tonight and out soon! #NephJC
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