10 days until the #AADOCR2025 in New York City. Come visit our posters and hear from these amazing students about their work on genetic and epigenetics of orofacial clefts. #uiowadentistry #uiowaresearch #cleftlipandpalate #epigenetics #uicod #womeninscience #genetics #twinstudies #nidcr #aadocr2025

Methylation quantitative loci analysis in nonsyndromic orofacial clefts Objectives: Nonsyndromic orofacial clefts (OFCs) etiology involves multiple genetic and environmental factors with over 60 identified risk loci; however, they account for a minority of the estimated r...

New preprint from the Petrin Lab: doi.org/10.1101/2025...
We show that non-coding cleft-associated SNPs can affect cleft risk through DNA methylation (meQTLs). #uiowadentistry #uiowaresearch #cleftlipandpalate #epigenetics #womeninscience #twinstudies #nidcr #meqtl

PAR-25-346: Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed) NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed) PAR-25-346. NCI

From #NCI & #NIDCR: "Exploratory/Developmental Bioengineering Research Grants" (R21) for #bioengineering innovations to improve the quality, speed, efficacy, operability, costs, &/or accessibility of basic biomedical & preclinical research.
grants.nih.gov/grants/guide...

DNA Methylation Effects on Van der Woude Syndrome Phenotypic Variability - Amanda Seaberg, Waheed Awotoye, Fang Qian, Ligiane A. Machado-Paula, Lindsey Dunlay, Azeez Butali, Jeff Murray, Lina Moreno-... Objective Van der Woude Syndrome (VWS) presents with combinations of lip pits (LP) and cleft lip and/or cleft palate (CL/P, CPO). VWS phenotypic heterogeneity e...

Check out our new paper on DNA Methylation Effects on Van der Woude Syndrome Phenotypic Variability. #uiowadentistry #uiowaresearch #cleftlipandpalate #epigenetics #vanderwoudesyndrome #lipits #uicod #womeninscience #proudmentor #nidcr #PetrinLab
doi.org/10.1177/1055...

Multi-omic analyses of a twin pair with mirror image cleft lip identifies pathogenic variant in FGF20 modified by differential methylation upstream of ZFP57 Background Disturbances in the intricate processes that control craniofacial morphogenesis can result in birth defects, most common of which are orofacial clefts (OFCs). Nonsyndromic cleft lip (nsCL),...

New preprint: Multi-omic analyses of a twin pair with mirror image cleft lip identifies pathogenic variant in FGF20 modified by differential methylation upstream of ZFP57. #uiowadentistry #twinstudies #uicod #cleftlipandpalate #nidcr #Epigenetics
www.medrxiv.org/content/10.1...