Happy to share our latest article in #CellReports on the role of methyltransferase #NNMT in early chronic kidney disease #CKD, spearheaded by Dr Lucie Chanvillard and co-led with Dr Alessandra Tammaro:

DOI: 10.1016/j.celrep.2025.116823

lnkd.in/gMApDkAf
#NUSMedicine #amsterdamumc
Enjoy the read

Wiping Out Ovarian Cancer Protective Cells. Univ. of Chicago oncologist attack ovarian cancer by destroying the cells that protect it from therapy. #ovarian #cancer #immunotherapy #supportcells #nnmt

#1 名もなく、淡い | 忍たま名前変換 - MOCO太の小説シリーズ - pixiv 小平太夢 夢主は年上、臨時教師設定です。 両片想い状態です。 表紙絵はACOさんに描いていただいてます。

小平太カッコいいですよね…いい男

名もなく、淡い | MOCO太 #pixiv www.pixiv.net/novel/show.p...
#rkrnプラス
#nnmt

小平太は夏が似合うよね☀️

※もこたの小説の表紙用になる予定

#RKRN
#RKRNプラス
#nnmt

A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male We present a case study of a 20-year-old male with an unknown neurodegenerative disease who was referred to the Undiagnosed Diseases Network Vanderbilt Medical Center site. A previous metabolic panel ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Global metabolic profiling of those plasma samples revealed an error in metabolism related to nicotinamide N-methyltransferase ( #NNMT) activity."

A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male We present a case study of a 20-year-old male with an unknown neurodegenerative disease who was referred to the Undiagnosed Diseases Network Vanderbilt Medical Center site. A previous metabolic panel ...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Here, nicotinamide is converted to either 1-methylnicotinamide by the enzyme nicotinamide N-methyltransferase ( #NNMT) or to nicotinamide mononucleotide ( #NMN) by nicotinamide phophoribosyltransferase ( #NAMPT)."

A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male We present a case study of a 20-year-old male with an unknown neurodegenerative disease who was referred to the Undiagnosed Diseases Network Vanderbilt Medical Center site. A previous metabolic panel ...

pmc.ncbi.nlm.nih.gov/articles/PMC...
"Our findings showed that the patient’s nicotinamide N-methyltransferase ( #NNMT), a key enzyme in NAD(H) biosynthesis and methionine metabolism, was not functional under normal fed or fasting conditions but was restored in response to the nicotinamide challenge"

A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male We present a case study of a 20-year-old male with an unknown neurodegenerative disease who was referred to the Undiagnosed Diseases Network Vanderbilt Medical Center site. A previous metabolic panel ...

A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male #NNMT #NAD #NADH #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

NNMT promotes tubular senescence and fibrosis in chronic kidney disease Chronic kidney disease (CKD) is a major global health issue, projected to become the fifth leading cause of mortality by 2040. Renal tubular cell senescence is a key driver of kidney fibrosis, the fin...

Excited to share the preprint of the latest work showing that #NNMT is a promising target in the early stage of #CKD preserving tubular homeostasis and reducing cellular #senescence

www.biorxiv.org/content/10.1...

#kidneydisease #senescence #fibrosis #NNMT #proximaltubule