#antisense #GBM #exon #oligonucleotides #midline
#hystone
bsky.app/profile/bior...

⭐NAR Breakthrough! ⭐
#RNAtherapeutics show strong promise for #CNSdisorders 🧠. #Preclinical studies reveal that very high doses of #oligonucleotides can cause brief, reversible neuronal activation driven by metal ion interactions 🧪.
Read the full article here: doi.org/10.1093/nar/...

MALDI Users’ Day today at King’s College London.

As someone who’s always loved chromatography, it’s inspiring to see the breadth of applications where MALDI is making such an impact. The speed is remarkable, firing the laser to generate near-instantaneous spectra.
#oligonucleotides
#polymers

🔬siRNA therapies are revolutionizing medicine!
Challenges: rapid degradation, poor biodistribution, cell barriers & off-target effects.Innovative delivery systems are the game-changer.
📍OTDC 2026|May25–26,Rome,Italy.
oligo-nucleotide.com
#siRNA #RNAresearch #Nanomedicine #Oligonucleotides #siRNA

Navigating the bioanalytical complexities of oligonucleotide therapeutics Eshani Galermo explores the technological advances that are shaping the future of oligonucleotide quantitation and characterization.

Oligonucleotide therapeutics = new hope, new challenges.

SCIEX expert Eshani Galermo explains how advanced LC-MS strategies and emerging technologies are shaping bioanalysis.

Read more: www.bioanalysis-zone.com/sciex-itz-na...

#Bioanalysis #Oligonucleotides #DanaherNews

Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages Abstract. Antisense oligonucleotides hold great promise in the treatment of disease, but their efficacy is limited by modest bioavailability and toxicity.

Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages academic.oup.com/nar/article/...
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids

ASOG: AntiSense Oligonucleotide Generator. #Oligonucleotides #ComputationalStructuralBiotechnology 🧬 🖥️
www.sciencedirect.com/science/arti...

From #CRISPR-based genome editing to data storage, #oligonucleotides are at the forefront of precision medicine. Explore their role in creating new functions and advancing scientific research in this month's #SCIEX #SpotlightOnSeries topic: bit.ly/41sahev

Analyzing #oligonucleotides can be tricky due to their instability and complex analysis. But with the #SCIEX 7500+ system, we can achieve high sensitivity *and* accuracy.

Discover how in this month's 🔎 Spotlight On 🔦 #oligos: bit.ly/41sahev

🔬 Dr. Anna Aviñó, coordinator of NANBIOSIS U29, advances therapeutic & diagnostic oligonucleotides through innovative nucleic acid chemistry.

Learn more about our researchers: www.nanbiosis.es/anna-avino/

#NanbiosisExpertise #ICTSnews #CEBS #CEBiomedS #ResearchExcellence #Oligonucleotides

🔬 Analyzing #oligonucleotides can be tricky due to their instability and complex analysis.

But with the SCIEX 7500+ system, we can achieve high sensitivity and accuracy. Discover how in this month's #SpotlightOn oligos 👉 bit.ly/41sahev

#Quantitation #LCMSAnalysis #SCIEX7500Plus

🔬 Our Oligos explainer: A new frontier in precision medicine, explores the rise of #Oligonucleotides, an emerging class of complex medicines transforming #DiseaseTreatment ➡️ oligosexplainer.org

The report highlights the potential of this breakthrough and why the sector must embrace its benefits. 🤝

Made-to-order DNA goes big: new tech doubles size of custom genetic sequences Enzyme-based techniques and refinements in organic chemistry ease the generation of extended DNA sequences.

Made-to-order DNA goes big: tech doubles size of custom genetic sequences
www.nature.com/articles/d41...
* enzyme-based tech
* refined organic chemistry
* generation of extended DNA seq

#MolecularBiology #PolynucleotideChemistry #SyntheticDNA #SyntheticBiology #GeneticEngineering #oligonucleotides

Microbubble-driven nanoparticles deliver gene suppressors to break down MRSA biofilms A major cause of hospital-acquired infections, the super bacteria Methicillin-resistant Staphylococcus aureus (MRSA), not only exhibits strong resistance to existing antibiotics but also forms a…

Microbubble-driven nanoparticles deliver gene suppressors to break down #MRSA #biofilms ...

| #infections | #Staphylococcus | #antibiotics | #oligonucleotides | Via @sciencex.bsky.social‬

#chemistry #conferences #peptides #oligonucleotides #foldamers

In this review, Ruairí Brannigan and co-researchers @dublincityuni.bsky.social highlight the significant advancements in polymer-assisted delivery of antisense #oligonucleotides (ASOs) and their potential in precision disease treatment.
➡️ https://tinyurl.com/46y7j39a
#BJNANO 💎 🔓
@r2b2-13.bsky.social

Orfonyx Bio – big ambitions in protein upregulation Orfonyx Bio is looking to make its mark as a leader in protein upregulation for clinical benefit – and has made technical progress towards this goal over the past two years. In that time as a BioEscal...

Some press regarding Orfonyx Bio - a spin-out company that I founded a few years ago #OrfonyxBio #oligonucleotides

🔬 Our newly released Oligos explainer: A new frontier in precision medicine explores the rise of #Oligonucleotides, an emerging class of complex medicines transforming #DiseaseTreatment ➡️ oligosexplainer.org

The report highlights why the sector must embrace the potential benefits of this treatment🤝

🟢 NUCLEOTIDE & OLIGONUCLEOTIDE💪💚
To understand the roles of nucleotides and oligonucleotides in our bodies, it's essential to.. ⬇️
facebook.com/share/v/15suFq…
Staysafe #Stayhealth #Nucleotides #Oligonucleotides #AIalgorithms #dussrc2025healthprotocols

Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease - Communications Medicine Karjosukarso et al. investigate antisense oligonucleotides targeting aberrant splicing caused by a recurrent ABCA4 variant in Stargardt disease. A candidate therapeutic molecule that shows a favorable...

Check out our latest work! Preclinical in vitro and safety and in vivo biodistribution of #antisense #oligonucleotides targeting a recurrent genetic variant in ABCA4 present in patients with #Stargardt disease. A big first step towards therapeutic intervention.
www.nature.com/articles/s43...

12 PhDs on Antisense oligonucleotide research to foster the full therapeutic potential of antisense technology across tissues EFFecT (European Training Program to Foster the Full Therapeutic Potential of Antisense Technology across Tissues) is a Marie Skłodowska-Curie Doctoral Network (2025-2028), offering 12 PhD positions.

🚨 We're hiring! 🚨

Join us at Biobizkaia 🌍 as part of the MSCA-DN EffecT project! We’re offering a fully funded #PhD position UPV/EHU. 🎓

📌 Focus on:
🔬 #Antisense #oligonucleotides
🧬 #Splicing
🌟 #Rarediseases📄

Apply now: euraxess.ec.europa.eu/jobs/296420
Info here: www.effect-dn.eu/candidates