Dark gray background with a slightly lighter square centered in the middle. Yellow-green quotation mark outlines appear in the top left and bottom right corners of the square. At the top of the square, in yellow-green text, is the citation: Gangwal A, Lavecchia A. doi:10.1016/j.drudis.2025.104360. Below the citation is a quote in matching yellow-green text: "Machine learning (ML) and deep learning (DL) algorithms, which are subfields of AI, can analyze complex biological systems to predict drug behavior, toxicity, and efficacy with greater precision than traditional animal models, which are often hindered by species differences."

In this review, Gangwal & Lavecchia examine how AI-powered #OrganChips & #DigitalTwins can overcome the limitations of animal experiments in #DrugDiscovery, highlight real-world applications, limitations, & strategies to make #AI innovations more reliable & scalable. 🧪
doi.org/10.1016/j.dr...

We need to simplify the engineering so that we can complicate the biology #NAMs #MPS #OrganChips

Figure 1 from the linked preprint: "OrganoidChip+’s dimensions and principle of work. (a) The chip schematic depicting its height dimensions and various compartments such as the inlet, perfusion channel (PC), culture chamber (CC), trapping areas (TAs) consisting of staging chambers (SCs) and immobilization chambers (ICs), filter channels (FCs), exit chamber (EC), and serpentine exit channel. The serpentine exit channel with a length of 43.5 mm and a width of 215 µm generates a hydrodynamic resistance of 3 × 1012 (N.s/m5) to avoid high flow rates and shear stress inside the chip. (b) Various steps for cell seeding (i), organoid culture (ii), and immobilization (iii) in the chip. (i) For seeding, the Luer stub is inserted into the culture chamber, the cell suspension is dispensed with a rotating movement to fill the entire culture chamber. (ii) Organoids grow efficiently while accessing nutrients from all direction surrounding the culture chamber. (iii) Matrigel is digested, and organoids are pushed into the TAs for immobilization while some organoids are natively immobilized by adhering to the glass in the culture chamber. (c) Side view of the same steps depicted in (b). The organoids in the culture chamber are imaged using brightfield microscopy every day to track their growth. After 7 days of culturing, Matrigel is digested to enable organoid immobilization within TAs. After immobilization, organoids can be fluorescently labelled and imaged at high-resolution on the chip. Scale bars represent 1 mm in (a-b) and 400 µm in (c)."

You've heard of #organoids and #organchips, but what about an OrganoidChip+? 🧪

Scientists at @utbiomedical.bsky.social & UGA developed this new, imaging-ready #microfluidic platform for research, drug screening, & disease modeling.

Preprint by Moshksayan et al.
www.biorxiv.org/content/10.1...

In the spirit of 🩷 Valentine's Day 🩷 , we've written a little ode to #OrganChips, inspired by the recent Heart-Chip publication from Cedars-Sinai!

*Ahem*

How will MPS-based models such as #OrganChips enable breakthrough discoveries in human life sciences? Read the latest t4 workshop report to learn how MPS technology will help drive a new era of human-centric research: pubmed.ncbi.nlm.nih.gov/39827406/

💰 #NIHGrant opportunities for investigators using #ML, #omics, #insilico models, #organchips, and other novel tools to study maternal and pediatric pharmacology and therapeutics. Applications open in January!
grants.nih.gov/grants/guide...

Check out this human-relevant research #funding opportunity from #NIAID! Submit your applications to use #organchips, #organoids, #bioprinting, and #exvivo models for studying human #radiation exposure and developing medical countermeasures.
grants.nih.gov/grants/guide...

George Mason scientist secures $1.4M DTRA grant to study viruses’ impact on organ health College of Science researcher Aarthi Narayanan recently secured a $1.4M grant from the Defense Threat Reduction Agency (DTRA) to investigate how an infection spreads between organs, and how a therapeu...

George Mason University's Aarthi Narayanan recently won a $1.4 million grant from the Defense Threat Reduction Agency Dr. Narayanan & her team will use human #organchips to study how viruses spread between organs in the human body.
#pandemicpreparedness #virology
provost.gmu.edu/news/2024-10...