#pharmSky

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity | Nature How a local infection triggers systemic humoral immunity remains unclear. Here we identify farnesyl pyrophosphate (FPP), a mevalonate pathway metabolic intermediate1, as an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20. This signalling axis potentiates the differentiation of T follicular helper cells and migratory dendritic cells2,3. FPP accumulates within keratinocytes after infection or ultraviolet irradiation through the activation of the mevalonate pathway mediated by the unfolded protein response–SREBF pathway, amplifying germinal centre (GC) responses in draining lymph nodes. Mechanistically, accumulated FPP in the cytosol engages transient receptor potential vanilloid 3 (TRPV3) by binding to its intracellular domains, inducing Ca2+ influx that subsequently activates the calmodulin–calcineurin–NFAT and PYK2–RAS–ERK pathways to enhance IL-6 and CCL20 production. This FPP–TRPV3–IL-6/CCL20–GC axis potentiates pathogen-specific an

FPP, a metabolite, boosts IgG via IL-6 & CCL20 from keratinocytes, aiding Tfh & dendritic cells. From infection to systemic immunity—power of biology! PMID:41781621, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10167-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Pre-splicing conformation and stepwise circularization of a group I intron in Azoarcus pre-tRNA | Nature Communications Group I introns are catalytic RNAs capable of self-splicing, yet structural insights into full-length precursor RNAs and post-splicing circularization have been limited. Here, we present cryo-EM structures of the Azoarcus pre-tRNAIle system across key catalytic stages, including the full-length precursor in Pre-1S conformations, the linear intron, and the circular introns, at 2.8-3.3 Å resolution. These structures reveal a preformed P1 helix, register shifts during splicing, and a conformational flip of G37 that stabilizes the circularization site. Biochemical analyses confirm a two-step circularization mechanism, generating a secondary circular product via an alternative ligation site. Together, our results provide an atomic-level view of a group I intron system through splicing and circularization. This work uncovers structural principles governing RNA conformational dynamics, catalysis, and circular RNA formation, with broad implications for ribozyme engineering. Cryo-EM structures

Discover cryo-EM insights: See group I intron in Azoarcus pre-tRNA^Ile across key stages. Pre-splicing & circularization detailed at 2.8-3.3 Å! 🌟 PMID:41862486, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70747-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1038/s41577-026-01273-7 No description available

Mucosal vaccines target entry sites of pathogens, triggering resident T/B cells & local antibody production to stop infections. PMID:41699393, Nat Rev Immunol 2026, @NatRevImmunol https://doi.org/10.1038/s41577-026-01273-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A cute drawing of a pill holding a plant and the message: switch to PO, great for patients, better for our planet

Happy Earth Day, and switch to PO! 🌱💊

#IDSky #MedSky #PharmSky

@sustainabil-id.bsky.social

#pharmsky

The Great Lakes Chapter of ASPET's 2026 annual meeting on "Advances in GLP-1 Pharmacology: Obesity and Beyond" will be held on June 12, 2026 at Midwestern University in Downer's Grove, Illinois.

The @glcaspet.bsky.social will hold its 39th Annual Scientific Meeting on Friday, June 12, 2026 at Midwestern University in Downers Grove. The theme of the 2026 meeting is “Advances in #GLP-1 Pharmacology: #Obesity and Beyond.” #Science 🧪 #PharmSky 💊 www.aspet.org/aspet/member...

Biomedical scientists: make sure you attend the 39th Annual Scientific Meeting of ASPET's Great Lakes Chapter on Friday, June 12th. This year's theme is "Advances in GLP-1 Pharmacology: Obesity and Beyond."

Discount registration ends May 15: https://ow.ly/nTs350YO5Fp
#pharmsky 🧪

Biomedical scientists: make sure you attend the 39th Annual Scientific Meeting of ASPET's Great Lakes Chapter on Friday, June 12th. This year's theme is "Advances in GLP-1 Pharmacology: Obesity and Beyond."

Discount registration ends May 15: https://ow.ly/nTs350YO5Fp
#pharmsky 🧪

IUPHAR International Forum for Early Career Researchers on Pharmacology of NP & TM. Marine Natural Products Pharmacology. Register https://www.cnphars.org.cn/meeting/2026/May82026/ or write to zhaoying@imm.ac.cn to receive zoom meeting information.

#NaturalProducts #Science 🧪 #PharmSky 💊 Register here www.cnphars.org.cn/meeting/2026...

⭐NEW EPISODE⭐It's time to make pharmacy MAC appeals & state-level enforcement work for pharmacies.

Reclaiming Pharmacy Revenue: State-Level Enforcement & MAC Appeals | The #PUTTcast

🎧Catch The Episode Now!🎧
youtu.be/gOg2dN4b7y0

#PharmSky #independentpharmacy #podcast #PharmacyBusiness #PBMreform

https://doi.org/10.1001/jamadermatol.2025.4855 No description available

Man in 30s with 3-month nail matrix damage on left thumbnail; diagnosed with nail sarcoidosis. Insightful. PMID:41563737, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2025.4855 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://www.cell.com/cell/fulltext/S0092-8674(25)01422-9 No description available

EcDNAs drive oncogenic fusion transcript amplification, with the highest rate of fusion events among all copy-number alterations across diverse cancers. PMID:41506267, Cell 2026, @Cell www.cell.com/cell/fulltext/S0092-8674... #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamapsychiatry.2026.0021 No description available

JAMA Psychiatry found that health plan disenrollment increases all-cause & overdose mortality among MOUD patients. 📊💊 PMID:41779402, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.0021 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Alzheimer’s Aβ catalyzes Tau phase separation and aggregation via early nanocluster solubilization | Nature Communications Extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated Tau are the two main pathological hallmarks of Alzheimer’s disease (AD). Although the co-occurrence and synergistic effects of Aβ and Tau are well established, the mechanisms underlying their interplay in a biomolecular condensate environment remain unclear. Here we show that Aβ40 does not undergo liquid–liquid phase separation (LLPS) but significantly enhances Tau phase separation and is recruited into Tau condensates. This recruitment alters condensate physicochemical properties, accelerates liquid-to-solid maturation, promotes Tau amyloid fibril formation, and increases Tau-mediated cytotoxicity. Notably, prior to condensate formation, Aβ40 transiently solubilizes Tau nanoclusters into smaller species. Simulations further indicate that early interactions are non-specific and mediated by Tau repeat domains, ultimately promoting pathogenic aggregation. These finding

Alzheimer's Aβ40 enhances Tau phase separation and aggregation by solubilizing early nanoclusters, revealing key interplay in disease pathology. PMID:41807382, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70083-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A person stands smiling in a library archive, surrounded by shelves filled with books and boxes. They rest a hand on an open filing cabinet drawer containing organized folders. The background is full of colorful sticky notes.

Professor Lucas Richert has received an Honorary Membership from the American #Pharmacists Association for his work bridging #pharmacy's past with its present and future.

Learn how he's been documenting, contextualizing, and elevating the evolving role of pharmacy. #PharmSky https://bit.ly/3NT5vm0

Excited to share that our latest review marine compounds for various medical uses has been published in Marine Drugs 🧪💊 #science #pharmsky www.mdpi.com/1660-3397/24...

https://doi.org/10.1126/science.ads1246 No description available

Etv3 in dendritic cells is key for maintaining immune balance; its absence causes Treg cell expansion and T cell activation issues. 🧬 PMID:41678619, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.ads1246 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1056/NEJMoa2508820 No description available

Phase 1 trial shows potential for rezatapopt, a p53 reactivator, in treating TP53 Y220C-mutated tumors over a 21-day cycle. Exciting prospects! PMID:41740031, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2508820 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamaneurol.2026.0240 No description available

A study in JAMA Neurology finds high EBV-derived EBNA-1 antibody titers could help distinguish MS from MOGAD and NMOSD. PMID:41801194, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.0240 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Identification of an allosteric site on the E3 ligase adapter cereblon | Nature Cereblon (CRBN) is the target of thalidomide derivatives1 that achieve therapeutic efficacy against some haematologic neoplasias2–4 by recruiting neosubstrates for degradation5–7. Despite the intense investigation of orthosteric thalidomide derivatives, little is known about alternate binding sites on CRBN. Here we report an evolutionarily conserved cryptic allosteric binding site on CRBN. Small-molecule SB-405483 binds the allosteric site to cooperatively enhance the binding of orthosteric ligands and alter their neosubstrate degradation profiles. A survey of over 100 orthosteric ligands and their degradation targets reveals trends in the classes of compounds and neosubstrates in which degradation outcomes are enhanced or inhibited by SB-405483. Structural investigations provide a mechanistic basis for the effects of the allosteric ligand by shifting the conformational distribution of CRBNopen to a novel CRBNint and increasing the CRBNclosed state. The discovery of a cryptic allosteri

Discovery: Cereblon has a conserved allosteric site. SB-405483 binds there, boosting function. Key for new therapeutic strategies beyond thalidomide derivatives. PMID:41565821, Nature 2026, @Nature https://doi.org/10.1038/s41586-025-09994-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamapsychiatry.2025.4638 No description available

Study predicts which adolescents benefit from school mindfulness via baseline traits; crucial step as depression starts young. PMID:41706471, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2025.4638 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamaneurol.2026.0072 No description available

A pilot RCT at Univ. of Pittsburgh studied low-dose lithium7 for MCI. It assessed cognition & biomarkers. Feasible & safe! PMID:41770546, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.0072 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wait a second, why is atovaquone only available in that gross yellow liquid, but atovaquone-proguanil is in tablet form?? #IDsky #PharmSky

https://doi.org/10.1126/science.aec0173 No description available

New policies can boost diagnostic innovation. Investments could address 90% of global disease burden, impacting millions worldwide. PMID:41955384, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aec0173 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1056/NEJMoa2600752 No description available

Setidegrasib (ASP3082) tested for KRAS G12D involvement: targets NSCLC (5%) & pancreatic cancer (40%). Phase 1 study examined safety & efficacy. PMID:41879829, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2600752 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Gabapentinoids found to increase risk of drug toxicity Study results have suggested that patients who take gabapentinoids are at greater risk of drug toxicity if they are also taking another medication. Publishing their findings in PLoS Medicine on 16 Apr...

#Medsky🧪 #Pharmsky #publichealth study found that patients taking gabapentinoids with benzodiazepines were at double the risk of being hospitalised with drug poisoning, while combining the drug with opioids has a 30% increase in risk.
pharmaceutical-journal.com/article/news...

Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma | Nature Communications Myasthenia gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular transmission and motor symptoms. Its genetic background remains unclear, particularly beyond specific subtypes reported in European populations. Here, we perform a genome-wide association study (GWAS) of 1,434 MG cases covering all disease subtypes and 42,913 controls of Japanese, which newly identify the TERT locus (odds ratio [OR] = 1.31, P = 1.7×10-10). Subtype-stratified GWASs show stronger signals for generalized MG (gMG; OR = 1.38, P = 1.6×10-12), anti AChR antibody-positive gMG (g-AChR-Ab(+)MG; OR= 1.49, P = 2.1×10-15), and thymoma-associated gMG (g-TAMG; OR = 1.92, P = 1.1×10-15). Fine-mapping of the major histocompatibility complex region reveal distinct associations of HLA-DRB1 with late onset gMG (g-LOMG) and HLA-A with early onset gMG (g-EOMG). The MG risk TERT lead variant rs2736099 is associated with poor treatment response, especially in g-AChR-Ab(+)MG and g-EOMG (P < 0.0042). The

Genome-wide study of 1,434 Japanese MG cases reveals TERT locus (OR=1.31, P=1.7x10^-10) as key. This insight could reshape MG treatment strategies. PMID:41820352, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70376-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Looking forward to seeing you at this exciting
ESCMID Late-breaking session on Sunday
👇👇

@escmid.bsky.social @cmijournal.bsky.social @cmicomms.bsky.social @unmc-id.bsky.social #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #TxID #meded #Pharmsky #Pharmed #RXSky #MicroSky #ClinMicro

https://doi.org/10.1038/s41556-026-01896-x No description available

Discover the mitochondrial transfer network between Leydig cells and testicular macrophages crucial for testosterone synthesis!🔥💡 PMID:41760931, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01896-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1038/s41556-026-01879-y No description available

Tumor acidosis induces a CS-enriched glycocalyx, enhancing lipid scavenging and resisting ferroptosis. Exciting insights! PMID:41673170, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01879-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪