Graphical abstract illustrating the proposed mechanism by which prenatal OLA exposure disrupts placental vascular development, leading to intrauterine growth restriction (IUGR) in mice. Specifically, OLA released from orally ingested polylactic acid plastics during pregnancy interferes with GATA2-regulated VEGF signaling, thereby impairing placental vascular development. The mechanistic scheme was created using Figdraw.
#PolylacticAcid is a #biodegradable #plastic that can be broken down into oligomeric lactic acid (OLA) #nanoplastics. This study shows that OLA particles can accumulate in mouse #placenta & #fetus, inducing placental vascular dysplasia & fetal growth restriction @plosbiology.org 🧪 plos.io/4bR4e6W