Starvation-independent alarmone production inhibits translation through GTP depletion
- bioRxiv from @heatherfeaga.bsky.social
#ppGpp #Bsubtilis

Enzymatic Activity of PBP1B Compensates for β-lactam Mediated Inhibition of PBP2 in Cells Overproducing ppGpp The alarmone (p)ppGpp (ppGpp) accumulates in response to starvation and other stress, leading to inhibition of multiple biosynthetic pathways and, at high concentrations, suppression of bacterial grow...

Joint effort from lab alumnus Dr. Sarah Anderson and her fantastic undergraduate Isabella Mack on #ppGpp mediated control of cell wall synthesis in E. coli and the consequences for #AMR now up on @biorxiv-microbiol.bsky.social

www.biorxiv.org/content/10.1...

A shared alarmone–GTP switch controls persister formation in bacteria - Nature Microbiology Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.

A shared alarmone–GTP switch controls persister formation in bacteria
#Bacillussubtilis #ppGpp #dormancy

@natmicrobiol.nature.com from Jade Wang lab

www.nature.com/articles/s41...

a man with a mustache sits on a yellow swing ALT: a man with a mustache sits on a yellow swing

waiting for my favorite ligand to spawn in AF3 #ppGpp

Last Goley Lab pre-print of 2023! So proud of BCMB student Erika Smith for her stellar work demonstrating a role for proteolysis of the trnxnal regulator CdnL in adaptation to nutrient limitation. Read on if you love #ppGpp #Caulobacter #stressresponses #CdnL and/or #ClpXP. 1/