January 8, 2026: Study Design Paper Published for BEST-ICU - Rethinking Clinical Trials The study design paper for BEST-ICU has been published online in Trials. Congratulations to the study team on reaching this important milestone for all NIH Collaboratory Trials! The BEST-ICU trial […]

Congratulations to the BEST-ICU team on the publication of their study design paper! This innovative #pragmatictrial will evaluate strategies to increase adoption of the ABCDEF bundle in the ICU and improve care for critically ill adults in a variety of healthcare systems. duke.is/pctnews20260...

Should participants enrolled in pragmatic clinical trials without consent be notified? A complex decision that is context-specific, according to Stephanie Morain and colleagues. #pragmatictrial @stephaniemorain.bsky.social @bermaninstitute.bsky.social

December 2, 2025: Community Engagement Strategies Boost Rural Enrollment in FM-TIPS Fibromyalgia Trial - Rethinking Clinical Trials New findings from FM-TIPS show that targeted community engagement methods are highly effective in increasing recruitment and enrollment, particularly among rural participants who are typically underre...

A targeted community engagement strategy in the FM-TIPS #pragmatictrial was highly effective in increasing recruitment and enrollment, particularly among rural participants who are typically underrepresented in clinical research. #nihHEALinitiative

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A study snapshot and ethics updates are now available for APA-SM, an NIH Collaboratory Trial. This #pragmatictrial is testing an auricular point acupressure intervention for self-management of chronic pain in rural communities in South Carolina and Texas. duke.is/pctnews20251...