#proteinpalmitoylation

Palmitoylation of Tspan4 is essential for migrasome formation Wang et al. show that migrasome formation requires tetraspanin 4 palmitoylation regulated by DHHC6 and PPT1. This modification drives tetraspanin 4 cluster

Palmitoylation of Tspan4 is essential for migrasome formation. zDHHC6 and PPT1 are identified as the main enzymes regulating this modification. Hearty congratulations, Yuwei Huang and all coauthors.

#proteinlipidation #proteinpalmitoylation #zDHHC6 #PPT1

rupress.org/jcb/article-...

S-acylation and membrane localization of the small GTPase ARL15 are mediated by the Golgi S-acyltransferases ZDHHC7 and ZDHHC3 ARL15 is a member of the ARF-like (ARL) family of small GTPases, implicated in the regulation of ion homeostasis and metabolic signaling pathways. Although ARL15 has been suggested to undergo S-acylat...

S-acylation and membrane localization of the small GTPase ARL15 are mediated by the Golgi S-acyltransferases ZDHHC7 and ZDHHC3. Hearty congratulations, Kenji Kontani and all coauthors.
#proteinpalmitoylation #proteinlipidation

- Journal of Biological Chemistry www.jbc.org/article/S002...

Cycling molecular assemblies for Golgi imaging and disruption - Nature Communications Tan and colleagues present “cycling molecular assemblies” that borrow cellular lipidation machinery to build nanostructures inside the Golgi apparatus. These tools enable rapid organelle imaging and s...

Creative use of peptide chemistry, protein S-acylation/deacylation and supramolecular assembly for building tools to image Golgi. Led by the lab of Bing Xu at Brandeis @brandeisuniversity.bsky.social

#proteinpalmitoylation #ptoteinthioesterase #proteinlipidation

www.nature.com/articles/s41...

S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes - Nature Metabolism S-acylation of adipose triacylglyceride lipase, the rate-limiting enzyme of lipolysis, is shown to be required for lipolysis and lipid droplet homoeostasis in mice.

Many emerging connections between S-acylation and autophagy -

#S-acylation #proteinpalmitoylation #proteinlipidation

www.nature.com/articles/s42...

Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer’s disease | PNAS Protein post-translational modifications (PTM) play a crucial role in the modulation of synaptic function and their alterations are involved in the...

Fresh from the oven. #S-acylation #proteinpalmitoylation time

Could zDHHC7 probes make a difference here ?
www.pnas.org/doi/10.1073/...