Electroacupuncture Alleviates Memory Deficits in APP/PS1 Mice by Targeting Serotonergic Neurons in Dorsal Raphe Nucleus
This study shows that activating #Serotonergic neurons in the DRN restores cognition in #APP/PS1 mice via #5HT1B-mediated #Glutamatergic signaling & also suggests that #Electroacupuncture enhances #LearningAndMemory via DRN serotonergic pathways. #medsky
Read: doi.org/10.1007/s115...
Drosophila juvenile brain labeled for astrocyte-like glia and ensheathing glia. Spatial organization of astrocyte-like glia (right) and ensheathing glia (left) subclasses. These two glial populations sculpt brain circuit architecture, with coordinated activities in mediating critical period experience-dependent connectivity remodeling. Together, these glial subclasses provide a cellular mechanism for synapse pruning in response to experience that shapes circuitry in development and can re-open plasticity at maturity. Image Creator: Vanessa Miller
A previous @plosbiology.org study showed that #synapse elimination in a #Drosophila brain circuit depends on #glial #serotonergic signaling. This new study shows that serotonin coordinates 2 distinct classes of #glia, with MMP-1 acting downstream of 5-HT2AR activation 🧪 plos.io/48oSY00
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#glial #drosophila #synapse #glia #serotonergic #art #digitalart #transfur #transformation #tftuesday #tf #tfeveryday #furry #booksky #birds #vogels #pimpelmees #bluetit #soestdijk #opinião
🚀 BlueSky trending hashtags (15m):
#glial #drosophila #synapse #glia #serotonergic #art #digitalart #transfur #transformation #tftuesday #tf #tfeveryday #furry #booksky #birds #vogels #pimpelmees #bluetit #soestdijk #opinião
Drosophila juvenile brain labeled for astrocyte-like glia and ensheathing glia. Spatial organization of astrocyte-like glia (right) and ensheathing glia (left) subclasses. These two glial populations sculpt brain circuit architecture, with coordinated activities in mediating critical period experience-dependent connectivity remodeling. Together, these glial subclasses provide a cellular mechanism for synapse pruning in response to experience that shapes circuitry in development and can re-open plasticity at maturity. Image Creator: Vanessa Miller
A previous @plosbiology.org study showed that #synapse elimination in a #Drosophila brain circuit depends on #glial #serotonergic signaling. This new study shows that serotonin coordinates 2 distinct classes of #glia, with MMP-1 acting downstream of 5-HT2AR activation 🧪 plos.io/48oSY00
Drosophila juvenile brain labeled for astrocyte-like glia and ensheathing glia. Spatial organization of astrocyte-like glia (right) and ensheathing glia (left) subclasses. These two glial populations sculpt brain circuit architecture, with coordinated activities in mediating critical period experience-dependent connectivity remodeling. Together, these glial subclasses provide a cellular mechanism for synapse pruning in response to experience that shapes circuitry in development and can re-open plasticity at maturity. Image Creator: Vanessa Miller
A previous @plosbiology.org study showed that #synapse elimination in a #Drosophila brain circuit depends on #glial #serotonergic signaling. This new study shows that serotonin coordinates 2 distinct classes of #glia, with MMP-1 acting downstream of 5-HT2AR activation 🧪 plos.io/48oSY00
A first-in-human Phase 1 trial of #RE104, a short-acting #serotonergic #psychedelic prodrug, has just been published in JCP. In this placebo-controlled RCT, RE104 was safe and well-tolerated up to 30 mg, producing psychedelic effects that lasted about 3-4 hours.
🔗 journals.lww.com/psychopharma...
#Electroacupuncture-induced activation of #serotonergic neurons in the dorsal raphe nucleus alleviates #CognitiveDysfunction in APP/PS1 mice, by activating #glutamatergic neurons and enhancing #SynapticPlasticity. #AlzheimersDisease #medsky
#MostDownloaded: link.springer.com/article/10.1...
